遗传 ›› 2013, Vol. 35 ›› Issue (4): 410-420.doi: 10.3724/SP.J.1005.2013.00410
李辉辉, 黄萍, 董巍, 朱作言, 刘东
收稿日期:2012-08-20
修回日期:2012-11-14
出版日期:2013-04-20
发布日期:2013-04-25
通讯作者:
刘东
E-mail:doliu@pku.edu.cn
基金资助:国家自然科学基金委培育项目(编号：90919034)资助
LI Hui-Hui, HUANG Ping, DONG Wei, ZHU Zuo-Yan, LIU Dong
Received:2012-08-20
Revised:2012-11-14
Online:2013-04-20
Published:2013-04-25
摘要： 1972年美国俄勒冈大学George Streisinger教授开始研究斑马鱼(Danio rerio)至今, 斑马鱼以其独特的优点, 已经成为现代遗传学、发育生物学研究的重要模式动物。世界范围内斑马鱼研究群体的工作已奠定了较为完善的胚胎学、分子遗传学研究基础, 并且斑马鱼已被应用于开发人类重大疾病模型和药物筛选平台, 取得了许多有价值的研究成果。文章简述了斑马鱼成为模式动物的历史, 侧重介绍了业已建立的白血病、黑色素瘤、感染免疫疾病、神经疾病等斑马鱼模型, 以及利用斑马鱼进行小分子化合物/药物筛选和研发的现状。斑马鱼研究向生物医学方向的拓展, 必将为人类理解重大疾病发生机制、寻找疾病治疗方法, 为维护人类卫生、健康做出贡献。
李辉辉 黄萍 董巍 朱作言 刘东. 斑马鱼研究走向生物医学[J]. 遗传, 2013, 35(4): 410-420.
LI Hui-Hui, HUANG Ping, DONG Wei, ZHU Zuo-Yan, LIU Dong. A brief history of zebrafish research——toward biomedicine[J]. HEREDITAS, 2013, 35(4): 410-420.
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