[1] Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature, 2011, 473 (7347): 298-307.[2] Adams RH, Alitalo K. Molecular regulation of angiogene-sis and lymphangiogenesis. Nat Rev Mol Cell Biol, 2007, 8(6): 464-478.[3] You LR, Lin FJ, Lee CT, DeMayo FJ, Tsai MJ, Tsai SY. Suppression of Notch signalling by the COUP-TFII tran-scription factor regulates vein identity. Nature, 2005, 435(7038): 98-104.[4] Geudens I, Gerhardt H. Coordinating cell behaviour during blood vessel formation. Development, 2011, 138(21): 4569-4583.[5] Herbert SP, Stainier DY. Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol, 2011, 12(9): 551-564.[6] Krishnan A, Almén MS, Fredriksson R, Schiöth HB. The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi. PLoS One, 2012, 7(1): e29817.[7] Liapakis G, Cordomi A, Pardo L. The G-protein coupled receptor family: actors with many faces. Curr Pharm Des, 2012, 18(2): 175-185.[8] Lappano R, Maggiolini M. G protein-coupled receptors: novel targets for drug discovery in cancer. Nat Rev Drug Discov, 2011, 10(1): 47-60.[9] Rivera-Lopez CM, Tucker AL, Lynch KR. Lysophos-phatidic acid (LPA) and angiogenesis. Angiogenesis, 2008, 11(3): 301-310.[10] Liu YJ, Wada R, Yamashita T, Mi YD, Deng CX, Hobson JP, Rosenfeldt HM, Nava VE, Chae SS, Lee MJ, Liu CH, Hla T, Spiegel S, Proia RL. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest, 2000, 106(8): 951-961.[11] Yukiura H, Hama K, Nakanaga K, Tanaka M, Asaoka Y, Okudaira S, Arima N, Inoue A, Hashimoto T, Arai H, Kawahara A, Nishina H, Aoki J. Autotaxin regulates vas-cular development via multiple lysophosphatidic acid (LPA) receptors in Zebrafish. J Biol Chem, 2011, 286(51): 43972-43983.[12] Contos JJ, Fukushima N, Weiner JA, Kaushal D, Chun J. Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc Natl Acad Sci USA, 2000, 97(24): 13384-13389.[13] Contos JJ, Ishii I, Fukushima N, Kingsbury MA, Ye X, Kawamura S, Brown JH, Chun J. Characterization of lpa2 (Edg4) and lpa1/lpa2 (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa2. Mol Cell Biol, 2002, 22(19): 6921-6929.[14] Kranenburg O, Poland M, van Horck FP, Drechsel D, Hall A, Moolenaar WH. Activation of RhoA by lysophos-phatidic acid and Gα12/13 subunits in neuronal cells: induc-tion of neurite retraction. Mol Biol Cell, 1999, 10(6): 1851-1857.[15] Ye XQ, Hama K, Contos JJ, Anliker B, Inoue A, Skinner MK, Suzuki H, Amano T, Kennedy G, Arai H, Aoki J, Chun J. LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature, 2005, 435 (7038): 104-108.[16] Sumida H, Noguchi K, Kihara Y, Abe M, Yanagida K, Hamano F, Sato S, Tamaki K, Morishita Y, Kano MR, Iwata C, Miyazono K, Sakimura K, Shimizu T, Ishii S. LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis. Blood, 2010, 116(23): 5060-5070.[17] Teo ST, Yung YC, Herr DR, Chun J. Lysophosphatidic acid in vascular development and disease. IUBMB Life, 2009, 61(8): 791-799.[18] Rosen H, Liao JY. Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm. Curr Opin Chem Biol, 2003, 7(4): 461-468.[19] Uhlenbrock K, Huber J, Ardati A, Busch AE, Kostenis E. Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. Cell Physiol Biochem, 2003, 13(2): 75-84.[20] Argraves KM, Wilkerson BA, Argraves WS. Sphingos-ine-1-phos |