遗传 ›› 2014, Vol. 36 ›› Issue (3): 220-227.doi: 10.3724/SP.J.1005.2014.0220

• 综述 • 上一篇    下一篇

组蛋白磷酸化修饰与精子发生

张朝晖1,2, 康现江1, 穆淑梅1   

  1. 1. 河北大学生命科学学院, 保定 071000; 
    2. 保定市妇幼保健院生殖医学科, 保定 071000
  • 收稿日期:2013-07-15 修回日期:2013-11-01 出版日期:2014-03-20 发布日期:2014-02-25
  • 通讯作者: 康现江, 教授, 博士生导师, 研究方向:生殖生物学。E-mail: xjkang@hbu.edu.cn E-mail:xjkang@hbu.edu.cn
  • 作者简介:张朝晖, 副主任医师, 在读博士研究生, 研究方向:生殖生物学。Tel: 0312-2093283; E-mail: zhizhi199999@163.com
  • 基金资助:

    国家自然科学基金项目(编号:312723095)资助

Histone phosphorylation and spermatogenesis

Zhaohui Zhang1,2, Xianjiang Kang1, Shumei Mu1   

  1. 1. College of Life Science, Hebei University, Baoding 071000, China; 
    2. Department of Reproduction Medicine, Maternal and Babies Health Center of Baoding, Baoding 071000, China
  • Received:2013-07-15 Revised:2013-11-01 Online:2014-03-20 Published:2014-02-25

摘要:

组蛋白磷酸化是组蛋白氨基酸残基的磷酸化修饰, 是一类重要的翻译后修饰, 与有丝分裂和减数分裂的染色质压缩、染色质功能调节、转录的激活与抑制、DNA损伤修复以及物质代谢等多种机制相关。文章对国内外近10年多种代表性生物精子发生(孢子形成)的相关文献进行总结, 论述了组蛋白磷酸化在精子发生中调控蛋白质作用因子的结合位点、调控减数分裂过程中的DNA复制与重组、保障正确的染色质重塑、对减数分裂后的成熟精子核的完全包装等重要功能。这些发现加深了人们对于组蛋白及其翻译后修饰在精子发生及分化中作用的理解。

关键词: 精子质量, 精子发生, 组蛋白磷酸化, 表观遗传

Abstract:

Histone phosphorylation is one of the most important post-translational modifications (PTMs) which play a key role in the chromatin remodeling process during spermatogenesis. Histone phosphorylation is related to distinct important biological processes, such as mitotic/meiotic chromosome condensation, chromatin function regulation, transcriptional activation or inactivation, double-strand DNA break repair, and other metabolic reactions. This review discusses the correlation between histone phosphorylation and spermatogenesis in different organisms from literatures published in the last decade. The critical functions of histone phosphorylation during spermatogenesis (sporogenesis) are summarized, such as binding sites involved in protein interaction, regulation of meiotic replication and/or recombination, correct chromatin remodeling, and chromatin compaction in the sperm nucleus (spore) after post-meiotic process. These findings will help build a solid foundation for further study, and also deepen our understanding of the roles for histones and their modifications in male germ cell development and differentiation.

Key words: sperm quality, spermatogenesis, histone phosphorylation, epigenetics