摘要： 端粒酶是真核细胞体内的一种核糖核酸蛋白质复合体，是一种特殊的DNA聚合酶，具有延伸DNA末端的功能，能够维持端粒长度和功能，TERT具有反转录酶活性。在大多数体细胞和原代细胞中，端粒酶活性很低，通常检测不到，但在肿瘤细胞中，端粒酶则被广泛激活，因此认为端粒酶与肿瘤的发生具有密切的关系，本文介绍了应用端粒酶阴性鼠研究端粒酶与G链悬垂和P53在肿瘤的发生过程中的相互关系。
Abstract: Telomerase is Ribonucleoprotein complex in eukaryocyte,which is composed of telomerase reverse transcriptase(TERT) and telomerase RNA.Telomerase is a special DNA polymerase which can extend the terminal of DNA and maitain the length of telomere.TERT have reverse transcriptase activity.Telomerase activity do not examine in most somatic cell and primary cell,but most tumor cell have strong telomerase activety.It was think that the telomerase has sthrong relation with tumor ocurrenss.In this article,the author instruct the correlation of G-strand and P53 in tumor occurness.