遗传 ›› 2002, Vol. 24 ›› Issue (3): 351-355.

• 论文 • 上一篇    下一篇

基因组内碱基分布整体均衡与局部不均衡的研究进展

钟东1;赵贵军2;张振书1;徐安龙2 ZHONG Dong1;ZHAO Gui-jun2;ZHANG Zhen-shu1;XUN An-long2   

  1. 1.第一军医大学南方医院消化疾病研究所,广州 510515; 2.中山大学生命科学院生物化学系,广州 510275 1.Gastroenterology Department,Nanfan Hospital,Guangzhou 510515,China; 2.Biochemistry Department,Zhongshan University,Guangzhou 510275,China
  • 收稿日期:1900-01-01 出版日期:2002-06-10 发布日期:2002-06-10

Advance in the Entire Balance and Local Unbalance of Base Distribution in Genome

  • Received:1900-01-01 Online:2002-06-10 Published:2002-06-10

摘要: 近年来,随着各种基因组计划的相继完成,发现在各种生物体单核苷酸链水平上存在着A≌T,G≌C的数量关系,但从几千个至十几万个碱基的范围来看,A≠T,G≠C。从数学上可以证明,如果DNA双链之间碱基的突变率一致,则A≌T,G≌C成立,但很多实验表明,双链之间的突变率并不一致,因此这个问题的解决仍有赖于数理科学和生物学的进一步结合。
Abstract:With more and more genome have been completely sequenced,scientists find the Partial Rule 2(PR2) in entire single strand that A≌T,G≌C.But from the scope of thousands to hundreds of thousand bases,A≠T,G≠C.Form the view of math,if the mutational rate of one strand is equal to others,it could be proved that A≌T,G≌C,but from the view of experience,that premise doesn't exist,so the solution of the problem needs the deeply combination of biology and math.

关键词: 基因组, 碱基分布, 生物信息学
Key words,
base distribution, genome