视网膜母细胞瘤基因1(RB1)研究进展

doi:10.3724/SP.J.1005.2010.01097

遗传 ›› 2010, Vol. 32 ›› Issue (11): 1097-1104.doi: 10.3724/SP.J.1005.2010.01097

视网膜母细胞瘤基因1(RB1)研究进展

刘双虎, 王守志, 张慧, 李辉

东北农业大学动物科学技术学院, 哈尔滨 150030

收稿日期:2010-04-07 修回日期:2010-05-23 出版日期:2010-11-20 发布日期:2010-11-25
通讯作者: 李辉 E-mail:lihui@neau.edu.cn
基金资助:
国家高技术发展计划(863)(编号：2006AA10A120), 黑龙江省教育厅面上项目(编号：11531025)和东北农业大学创新团队发展计划项目(编号：CXT006)资助

Research advances on RB1 gene

LIU Shuang-Hu, WANG Shou-Zhi, ZHANG Hui, LI Hui

College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China

Received:2010-04-07 Revised:2010-05-23 Online:2010-11-20 Published:2010-11-25
Contact: LI Hui E-mail:lihui@neau.edu.cn

摘要/Abstract

摘要： 视网膜母细胞瘤基因1(Retinoblastoma1, RB1)是人类第一个分离克隆的抑癌基因。RB1基因是细胞周期的负调控因子, 通过与转录因子结合调节细胞增殖和分化所需基因的表达, 从而维持细胞生长发育的平衡。因此, 该基因的功能与细胞周期、细胞衰老、细胞凋亡、细胞分化和生长抑制等有关。文章对RB1基因的结构、表达及其功能的研究进展进行了综述。

关键词: RB1基因, 结构, 表达, 细胞周期, 细胞分化, 生长抑制

Abstract: The retinoblastoma1 (RB1) gene is the first cloned tumor suppressor gene. As a negative regulator of the cell cycle, RB1 gene could maintain a balance between cell growth and development through binding to transcription factors and regulating the expression of genes involved in cell proliferation and differentiation. Thus, it is involved in cell cycle, cell senescence, growth arrest, apoptosis and differentiation. This review summarizes recent advances on the structure, expression, and function of RB1 gene.

Key words: cell cycle, differentiation, growth arrest, RB1 gene, structure, expression

刘双虎，王守志，张慧，李辉. 视网膜母细胞瘤基因1(RB1)研究进展[J]. 遗传, 2010, 32(11): 1097-1104.

LIU Shuang-Hu, WANG Shou-Zhi, ZHANG Hui, LI Hui. Research advances on RB1 gene[J]. HEREDITAS, 2010, 32(11): 1097-1104.

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视网膜母细胞瘤基因1(RB1)研究进展

Research advances on RB1 gene

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