miRNA及其靶位点多态性的研究进展

doi:10.3724/SP.J.1005.2010.01091

遗传 ›› 2010, Vol. 32 ›› Issue (11): 1091-1096.doi: 10.3724/SP.J.1005.2010.01091

miRNA及其靶位点多态性的研究进展

刘利英¹, 徐纪茹², 宋土生³, 黄辰³

1. 西安交通大学医学院生物医学研究实验中心, 环境与疾病相关基因教育部重点实验室, 西安 710061; 2. 西安交通大学医学院免疫学与病原生物学系, 西安 710061; 3. 西安交通大学医学院遗传学与分子生物学系, 环境与疾病相关基因教育部重点实验室, 西安 710061

收稿日期:2010-01-10 修回日期:2010-03-23 出版日期:2010-11-20 发布日期:2010-11-25
通讯作者: 黄辰 E-mail:hchen@mail.xjtu.edu.cn
基金资助:
国家自然科学基金项目(编号：30872481)和陕西省科技计划项目(No. 2006K09-G7-1)资助

Progress of polymorphism in microRNA and microRNA target sites

LIU Li-Ying¹, XU Ji-Ru², SONG Tu-Sheng³, HUANG Chen³

1. Key Laboratory of Environment and Genes Related to DiseasesMinistry of Education, the Central Laboratory For Biomedical Research, Medical School, Xi’an Jiaotong University, Xi’an 710061, China; 2. Department of Immunology and Microbiology, Medical School, Xi’an Jiaotong University, Xi’an 710061, China; 3. Key Laboratory of Environment and Genes Related to DiseasesMinistry of Education, Department of Genetics and Molecular Biology, Medical School, Xi’an Jiaotong University, Xi’an 710061, China

Received:2010-01-10 Revised:2010-03-23 Online:2010-11-20 Published:2010-11-25
Contact: HUANG Chen E-mail:hchen@mail.xjtu.edu.cn

摘要/Abstract

摘要： 微RNA(microRNA, miRNA)是一类进化上保守、长度为21~23 nt的非编码单链小RNA, 参与个体发育、器官形成、细胞增殖、分化和细胞凋亡等生物学过程, 并在其中发挥重要的调节作用。近年来研究发现, miRNA及其靶位点的多态将引起不同类型的疾患。文章主要从miRNA及其靶位点的多态类型, 以及由多态性引起的相关疾病等方面来阐述miRNA的最新进展。

关键词: miRNA, 疾病, 基因多态性

Abstract: MicroRNAs (miRNAs), which are evolutionarily well-conserved, 21- to 23-nucleotide-long, small non-coding RNAs, are widely involved in the regulation of multiple biological processes, such as development, organogenesis, cell proliferation, cell differentiation, and apoptosis. Recent studies have shown that polymorphism in miRNAs and their target sites are closely related to various diseases, such as tumor and cardiological diseases. This review introduces recent progresses on polymorphism in microRNAs and their targeting sites and the related diseases.

Key words: microRNAs, polymorphism, disease

刘利英，徐纪茹，宋土生，黄辰. miRNA及其靶位点多态性的研究进展[J]. 遗传, 2010, 32(11): 1091-1096.

LIU Li-Yang, XU Ji-Ru, SONG Cha-Sheng, HUANG Chen. Progress of polymorphism in microRNA and microRNA target sites[J]. HEREDITAS, 2010, 32(11): 1091-1096.

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miRNA及其靶位点多态性的研究进展

Progress of polymorphism in microRNA and microRNA target sites

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