Hippo/YAP信号通路在神经系统中的作用及机制研究进展

doi:10.16288/j.yczz.17-069

遗传 ›› 2017, Vol. 39 ›› Issue (7): 630-641.doi: 10.16288/j.yczz.17-069

Hippo/YAP信号通路在神经系统中的作用及机制研究进展

包笑妹¹(),何晴²,王莹¹,黄智慧¹(),袁增强³()

1. 温州医科大学基础医学院,温州 325035
2. 中国科学院大学,北京 100039
3. 军事医学科学院基础医学研究所,北京 100850

收稿日期:2017-03-01 修回日期:2017-04-04 出版日期:2017-07-20 发布日期:2017-06-08
作者简介:包笑妹,硕士研究生,专业方向：生理学。E-mail: 18267858062@163.com|黄智慧,博士,教授,研究方向：胶质细胞发育和疾病。E-mail: hzhzju021@163.com|袁增强,博士,教授,研究方向：神经退行性疾病分子机制。E-mail: zyuan620@yahoo.com
基金资助:
国家自然科学基金项目(31671071,81630026)

The roles and mechanisms of the Hippo/YAP signaling pathway in the nervous system

Bao Xiaomei¹(),He Qing²,Wang Ying¹,Huang Zhihui¹(),Yuan Zengqiang³(),

1. Department of Basic Medicine, Wenzhou Medical University, Wenzhou 325035, China
2. University of Chinese Academy of Sciences, Beijing 100039, China
3. Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China

Received:2017-03-01 Revised:2017-04-04 Online:2017-07-20 Published:2017-06-08
Supported by:
the National Natural Science Foundation of China(31671071,81630026)

摘要/Abstract

摘要：

Hippo信号通路高度保守,由一系列激酶级联反应构成,主要通过下游效应分子YAP(Yes-associated protein)/TAZ(transcriptional coactivator with PDZ-binding motif) 转录辅激活因子调控细胞增殖、凋亡和分化等活动,从而控制器官大小和组织发育稳态。在正常发育情况下,神经细胞数目、空间分布的精准调控对于大脑发育至关重要。近年来研究发现,Hippo/YAP信号通路在神经干细胞增殖分化、神经元前体细胞增殖、胶质细胞分化和激活、髓鞘化发育以及神经系统疾病的发生发展等方面发挥重要作用。因此,有必要对该信号通路在神经系统中的作用和机制进行深入系统地研究。本文对Hippo/YAP信号通路在神经系统中的最新研究进展进行了综述,以期为神经系统发育和神经损伤疾病的治疗提供理论基础。

关键词: Hippo信号通路, YAP, 神经系统, 神经干细胞, 神经前体细胞, 胶质细胞

Abstract:

The Hippo signaling pathway, consisting of a highly conserved kinase cascade and downstream transcription co-activators YAP (Yes-associated protein)/TAZ (transcriptional coactivator with PDZ-binding motif), plays a key role in tissue homeostasis and organ size control by regulating the proliferation, differentiation and apoptosis of cells. During normal development, the precise control of neural cell numbers and spatial distributions of these neural cells is important for brain development. Recent studies have shown that the Hippo/YAP signaling pathway is actively involved in the self-renewal of neural stem cells, proliferation of neural progenitor cells, differentiation and activation of glial cells, and myelination of glial cells as well as in the development of neurological diseases. Due to its prominent role in the nervous system, it is necessary to further study on this pathway. In this review, we summarize the recent studies and focus on the roles and mechanisms of the Hippo/YAP signaling pathway in the nervous system, and provide insights for neural development and neural injury diseases.

Key words: Hippo signaling pathway, YAP, nervous system, neural stem cells, neural progenitor cells, glial cells

包笑妹, 何晴, 王莹, 黄智慧, 袁增强. Hippo/YAP信号通路在神经系统中的作用及机制研究进展[J]. 遗传, 2017, 39(7): 630-641.

Bao Xiaomei, He Qing, Wang Ying, Huang Zhihui, Yuan Zengqiang, . The roles and mechanisms of the Hippo/YAP signaling pathway in the nervous system[J]. Hereditas(Beijing), 2017, 39(7): 630-641.

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