遗传 ›› 2016, Vol. 38 ›› Issue (7): 612-622.doi: 10.16288/j.yczz.16-042
符梅1, 徐克惠2, 许文明2
收稿日期:
2016-01-24
出版日期:
2016-07-20
发布日期:
2016-07-20
作者简介:
符梅,硕士研究生,专业方向:妇产科学。E-mail: 497783767@qq.com
基金资助:
Mei Fu2, Kehui Xu1, Wenming Xu1
Received:
2016-01-24
Online:
2016-07-20
Published:
2016-07-20
摘要: Dicer是微小非编码RNA生成的关键内切酶,介导微小RNA(micro RNA,miRNA)和小干扰RNA(small interfering RNA,siRNA)的产生,通过RNA干扰(RNA interference,RNAi)途径实现转录或转录后水平基因调控,在调节细胞增殖、分化、凋亡等方面起重要作用。近年来Dicer基因在生殖领域的研究越来越受关注,最近的研究表明Dicer与男性生精细胞发育、精子形成及成熟、精子活力和形态生成、卵泡发育、排卵及黄体形成、性激素合成、输卵管功能、子宫内膜容受性等方面都有密切关系。繁衍后代需要精子和卵子的共同参与,Dicer可能通过影响精子和卵子的数量或者质量进而导致胚胎发育异常,因此理解Dicer在雄性与雌性生殖的重要调节作用对于理解生殖调节异常相关的疾病如无精子症、复发性流产等的发病机制具有重要的作用。本文对Dicer在雄性生殖道与雌性生殖中的关键作用进行了综述,旨在进一步从分子层面深入理解Dicer与生殖相关疾病的关系。
符梅, 徐克惠, 许文明. Dicer调节生殖功能的研究进展[J]. 遗传, 2016, 38(7): 612-622.
Mei Fu, Kehui Xu, Wenming Xu. Research advances of Dicer in regulating reproductive function[J]. HEREDITAS(Beijing), 2016, 38(7): 612-622.
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