Dicer调节生殖功能的研究进展

doi:10.16288/j.yczz.16-042

遗传 ›› 2016, Vol. 38 ›› Issue (7): 612-622.doi: 10.16288/j.yczz.16-042

Dicer调节生殖功能的研究进展

符梅¹, 徐克惠², 许文明²

1. 成都中医药大学,成都611137 2. 四川大学华西第二医院,四川大学–香港中文大学生殖医学联合实验室,教育部出生缺陷与相关妇儿疾病重验室,成都 610041;

收稿日期:2016-01-24 出版日期:2016-07-20 发布日期:2016-07-20
作者简介:符梅,硕士研究生,专业方向：妇产科学。E-mail: 497783767@qq.com
基金资助:
国家重点基础研究计划(973计划) (编号：2012CB944903)和新世纪人才计划项目(编号：NCET-12-0382)资助[Supported by the National Basic Research Program of China (No; 2012CB944903) and the Program for New Century Excellent Talents in University of Ministry of Education(No; NCET-12-0382)]

Research advances of Dicer in regulating reproductive function

Mei Fu², Kehui Xu¹, Wenming Xu¹

1. Joint Laboratory for Reproductive Medicine, SCU-CUHK; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China;
2. Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China

Received:2016-01-24 Online:2016-07-20 Published:2016-07-20

摘要/Abstract

摘要： Dicer是微小非编码RNA生成的关键内切酶,介导微小RNA(micro RNA,miRNA)和小干扰RNA(small interfering RNA,siRNA)的产生,通过RNA干扰(RNA interference,RNAi)途径实现转录或转录后水平基因调控,在调节细胞增殖、分化、凋亡等方面起重要作用。近年来Dicer基因在生殖领域的研究越来越受关注,最近的研究表明Dicer与男性生精细胞发育、精子形成及成熟、精子活力和形态生成、卵泡发育、排卵及黄体形成、性激素合成、输卵管功能、子宫内膜容受性等方面都有密切关系。繁衍后代需要精子和卵子的共同参与,Dicer可能通过影响精子和卵子的数量或者质量进而导致胚胎发育异常,因此理解Dicer在雄性与雌性生殖的重要调节作用对于理解生殖调节异常相关的疾病如无精子症、复发性流产等的发病机制具有重要的作用。本文对Dicer在雄性生殖道与雌性生殖中的关键作用进行了综述,旨在进一步从分子层面深入理解Dicer与生殖相关疾病的关系。

关键词: miRNA, Dicer, 精子生成, 卵母细胞, 胚胎发育, 基因多态性

Abstract: Dicer, an RNAse III endonuclease, is critical for the biogenesis of small noncoding RNAs (microRNAs), including the biogenesis of microRNAs and small interfering RNAs, which transcriptionally and post-transcription ally regulate mRNA expression through binding to target mRNA and leading to subsequent mRNA degradation. Recent studies show that Dicer plays important roles in cell proliferation, differentiation and apoptosis. It has been attracted more and more attention in the reproductive field. In the male reproduction field, mouse model shows that Dicer is critical for the development of spermatogenic cell, sperm maturation, sperm motility and morphology. On the other hand, Dicer is broadly involved in not only follicular development, ovulation, luteinization, sex hormone synthesis, but also regulating the functions of the fallopian tube, endometrial receptivity in female reproduction. Since sperm and egg are the only two types of gametes for producing offspring, Dicer dysregulation may be the underlying cause of compromised embryo development through affecting the quantity or quality of sperm and eggs. Therefore, understanding the function of Dicer in reproduction of female and male is of great significance to study the pathogenetic mechanism related to dysfunctional reproduction, such as azoospermia and recurrent spontaneous abortion. We review the pivotal roles of Dicer in the male and female reproduction field in order to understand the relationship between Dicer and related disease.

Key words: miRNA, Dicer, spermatogenesis, oocyte, embryonic development, genetic polymorphism

符梅, 徐克惠, 许文明. Dicer调节生殖功能的研究进展[J]. 遗传, 2016, 38(7): 612-622.

Mei Fu, Kehui Xu, Wenming Xu. Research advances of Dicer in regulating reproductive function[J]. HEREDITAS(Beijing), 2016, 38(7): 612-622.

参考文献

[1] Kurzynska-Kokorniak A, Koralewska N, Pokornowska M, Urbanowicz A, Tworak A, Mickiewicz A, Figlerowicz M. The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities. Nucleic Acids Res , 2015, 43(9): 4365-4380.
[2] Hill DA, Ivanovich J, Priest JR, Gurnett CA, Dehner LP, Desruisseau D, Jarzembowski JA, Wikenheiser-Brokamp KA, Suarez BK, Whelan AJ, Williams G, Bracamontes D, Messinger Y, Goodfellow PJ. DICER1 mutations in familial pleuropulmonary blastoma. Science , 2009, 325(5943): 965.
[3] Foulkes WD, Priest JR, Duchaine TF. DICER1: mutations, microRNAs and mechanisms. Nat Rev Cancer , 2014, 14(10): 662-672.
[4] Peng JJ, Yan F, Chen HR, Chen JP. Progress of studies on Dicer structure and function. Hereditas(Beijing) , 2008, 30(12): 1550-1556. 彭杰军, 燕飞, 陈海如, 陈剑平. Dicer 结构和功能研究进展. 遗传, 2008, 30(12): 1550-1556.
[5] Maatouk DM, Loveland KL, McManus MT, Moore K, Harfe BD. Dicer1 is required for differentiation of the mouse male germline. Biol Reprod , 2008, 79(4): 696-703.
[6] Murchison EP, Stein P, Xuan ZY, Pan H, Zhang MQ, Schultz RM, Hannon GJ. Critical roles for Dicer in the female germline. Genes Dev , 2007, 21(6): 682-693.
[7] Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, Mills AA, Elledge SJ, Anderson KV, Hannon GJ. Dicer is essential for mouse development. Nat Genet , 2003, 35: 215-217.
[8] Forbes K, Farrokhnia F, Aplin JD, Westwood M. Dicer- dependent miRNAs provide an endogenous restraint on cytotrophoblast proliferation. Placenta , 2012, 33(7): 581-585.
[9] Zindy F, Lee Y, Kawauchi D, Ayrault O, Merzoug LB, Li Y, McKinnon PJ, Roussel MF. Dicer is required for normal cerebellar development and to restrain medulloblastoma formation. PLoS One , 2015, 10(6): e0129642.
[10] Lau PW, Guiley KZ, De N, Potter CS, Carragher B, MacRae IJ. The molecular architecture of human Dicer. Nat Struct Mol Biol , 2012, 19(4): 436-440.
[11] Chen LJ, Yang M, Chen Y, Sun HQ, Xu WM. Roles of miR-15b in endothelial cell function and their relevance to vascular diseases. Hereditas(Beijing) , 2015, 37(2): 121-127. 陈良榉, 杨明, 陈艳, 孙华钦, 许文明. miR-15b在内皮细胞的功能及其与血管相关性疾病的关系. 遗传, 2015, 37(2): 121-127.
[12] Burger K, Gullerova M. Swiss army knives: non-canonical functions of nuclear Drosha and Dicer. Nat Rev Mol Cell Biol , 2015, 16(7): 417-430.
[13] Johanson TM, Lew AM, Chong MMW. MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer. Open Biol , 2013, 3(10): 130144.
[14] Björkgren I, Sipilä P. The role of Dicer1 in the male reproductive tract. Asian J Androl , 2015, 17(5): 737-741.
[15] Kaneko H, Dridi S, Tarallo V, Gelfand BD, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra SS, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJC, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MMW, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature , 2011, 471(7338): 325-330.
[16] Nakagawa A, Shi Y, Kage-Nakadai E, Mitani S, Xue D. Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Science , 2010, 328(5976): 327-334.
[17] Li P, Zhu WJ. Advance on Dicer gene and its role in female reproduction. Chin J Med Genet , 2011, 28(3): 275-278. 李平, 朱伟杰. Dicer基因在女性生殖中的作用及研究进展. 中华医学遗传学杂志, 2011, 28(3): 275-278.
[18] Romero Y, Meikar O, Papaioannou MD, Conene B, Grey C, Weier M, Pralong F, De Massy B, Kaessmann H, Vassalli JD, Kotaja N, Nef S. Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects. PLoS One , 2011, 6(10): e25241.
[19] Korhonen HM, Meikar O, Yadav RP, Papaioannou MD, Romero Y,

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

Dicer调节生殖功能的研究进展

Research advances of Dicer in regulating reproductive function

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	吕香江, 郭静, 林戈. TRIP13基因新突变导致卵母细胞成熟阻滞为特征的女性不孕[J]. 遗传, 2023, 45(6): 514-525.
[2]	张楠, 张珏, 林戈. 哺乳动物卵母细胞的DNA损伤与修复研究进展[J]. 遗传, 2023, 45(5): 379-394.
[3]	王文龙, 张春霞. 哺乳动物卵子与早期胚胎中全转录组poly(A)尾研究进展[J]. 遗传, 2023, 45(4): 273-278.
[4]	王梓川, 张嘉祺, 李磊. 哺乳动物早期胚胎发育的体外研究[J]. 遗传, 2022, 44(4): 269-274.
[5]	朱艳, 魏明, 周晓, 邓林华, 仇剑, 李果, 周世强, 谢浩, 李德生, 王承东. 大熊猫(Ailuropoda melanoleuca) miRNA研究进展[J]. 遗传, 2021, 43(9): 849-857.
[6]	胡广伟, 张珍珍, 高焕. 文昌鱼左右体轴建立机制的研究进展[J]. 遗传, 2021, 43(2): 134-141.
[7]	魏勇, 何玉兰, 郑学礼. RNAi在抗蚊媒病毒感染中的研究进展[J]. 遗传, 2020, 42(2): 153-160.
[8]	杨鑫宇,贾振伟. 颗粒细胞EGF类因子信号通路在调控卵母细胞成熟和发育中的作用[J]. 遗传, 2019, 41(2): 137-145.
[9]	饶琳, 孟飞龙, 房冉, 蔡晨依, 赵小立. MicroRNA调控耳蜗毛细胞发育的分子机制[J]. 遗传, 2019, 41(11): 994-1008.
[10]	夏蒙蒙,申雪沂,牛长敏,夏静,孙红亚,郑英. MicroRNA参与调控睾丸支持细胞的增殖与粘附功能[J]. 遗传, 2018, 40(9): 724-732.
[11]	张婕妤,初亚男,邹秉杰,张晏洁,封利颖. 基于级联核酸侵入反应的real-time PCR法检测咽拭子样本中UGT1A16*基因多态性[J]. 遗传, 2018, 40(8): 668-675.
[12]	刘海龙, 谌阳, 高杨, 周玲, 韩晓松, 赵长志, 杨高娟, 陈毅龙, 杨慧, 谢胜松. 靶向miRNA前体不同类型sgRNA的丰度及特异性评估[J]. 遗传, 2018, 40(7): 561-571.
[13]	张俊玉,吕珊,牛慧敏,雷安民. 哺乳动物卵母细胞不对称分裂的研究进展[J]. 遗传, 2018, 40(4): 279-291.
[14]	肖娟, 王讯, 罗毅, 李晓开, 李学伟. 附睾小体功能蛋白及sRNA研究进展[J]. 遗传, 2018, 40(3): 197-206.
[15]	柯玉文,刘江. 动物早期胚胎发育中染色质结构的继承和重编程[J]. 遗传, 2018, 40(11): 977-987.