遗传 ›› 2021, Vol. 43 ›› Issue (9): 849-857.doi: 10.16288/j.yczz.21-209

• 综述 • 上一篇    下一篇

大熊猫(Ailuropoda melanoleuca) miRNA研究进展

朱艳, 魏明, 周晓, 邓林华, 仇剑, 李果, 周世强, 谢浩, 李德生, 王承东()   

  1. 中国大熊猫保护研究中心,大熊猫国家公园珍稀动物保护生物学国家林业和草原局重点实验室,成都 611830
  • 收稿日期:2021-06-11 修回日期:2021-07-28 出版日期:2021-09-20 发布日期:2021-08-23
  • 通讯作者: 王承东 E-mail:wolongpanda@qq.com
  • 作者简介:朱艳,硕士,研究方向:大熊猫遗传与生态。E-mail: zhuyan_494062079@163.com
  • 基金资助:
    大熊猫国际合作基金项目编号资助(GH201710)

Progress on miRNA in giant panda (Ailuropoda melanoleuca)

Yan Zhu, Ming Wei, Xiao Zhou, Linhua Deng, Jian Qiu, Guo Li, Shiqiang Zhou, Hao Xie, Desheng Li, Chengdong Wang()   

  1. State Forestry and Grassland Administration Key Laboratory of Conservation Biology for Rare Animals of the Giant Panda State Park, China Conservation and Research Center for the Giant Panda, Chengdu 611830, China
  • Received:2021-06-11 Revised:2021-07-28 Online:2021-09-20 Published:2021-08-23
  • Contact: Wang Chengdong E-mail:wolongpanda@qq.com
  • Supported by:
    Supported by Giant Panda International Cooperation Fund Project No(GH201710)

摘要:

MicroRNA (miRNA)是一类广泛存在于真核生物、长约22 nt的内源性非编码RNA。miRNA通过与靶基因mRNA特异性结合影响基因的表达,进而参与调控多种生物学过程。大熊猫(Ailuropoda melanoleuca)是我国特有的珍稀动物,备受全世界的关注。近年来,随着二代测序技术(next-generation sequencing, NGS)的普及,大熊猫miRNA陆续被发现和鉴定。本文综述了miRNA在大熊猫免疫反应、乳腺发育、精子冷冻耐受及其他生物学过程的研究进展,并探讨了大熊猫miRNA的研究前景,以期为深入研究大熊猫miRNA的调控机制和促进大熊猫繁育与保护工作提供科学参考和新思路。

关键词: 大熊猫, miRNA, 免疫反应, 乳腺发育, 精子冷冻耐受

Abstract:

MicroRNAs (miRNAs), a family of endogenous non-coding RNAs with a length of about 22 nucleotides, are widely found in eukaryotes. miRNAs can affect gene expression through specific bindings with mRNAs of target genes and participate in the regulation of a variety of biological processes. Giant panda is not only a unique rare animal in China, but also the focus of attention on wildlife preservation worldwide. In recent years, with the popularization of next-generation sequencing (NGS) technology, miRNAs in giant panda have been discovered and identified one after another. In this review, we focus on the research progress on miRNAs in giant panda, involved in immune response, mammary gland development, sperm freezing tolerance and other biological processes, and then discuss future research directions of miRNAs in giant panda, and thus providing the scientific references and new ideas for studying the regulatory mechanisms of miRNAs and promoting the breeding and protection of giant panda.

Key words: giant panda, miRNA, immune response, mammary gland development, sperm freezing tolerance