miR-15b在内皮细胞的功能及其与血管相关性疾病的关系

doi:10.16288/j.yczz.14-288

遗传 ›› 2015, Vol. 37 ›› Issue (2): 121-127.doi: 10.16288/j.yczz.14-288

miR-15b在内皮细胞的功能及其与血管相关性疾病的关系

陈良榉¹,杨明¹,陈艳¹,孙华钦¹,许文明^1,2

1. 四川大学华西第二医院,四川大学-香港中文大学生殖医学联合实验室,教育部出生缺陷与相关妇儿疾病重点实验室,成都610041;
2. 四川大学,四川大学华西第二医院妇产科,成都 610041

收稿日期:2014-08-29 出版日期:2015-02-20 发布日期:2015-01-19
通讯作者: 许文明,副研究员,硕士生导师,研究方向：生殖生物学与生殖医学。E-mail: xuwenming1973@163.com
作者简介:陈良榉,硕士研究生,专业方向：出生缺陷。Tel：028-85502290;E-mail: 248698579@qq.com
基金资助:
国家重点基础研究计划(973计划)(编号：2012CB944903)和新世纪人才计划项目(编号：NCET-12-0382)资助

Roles of miR-15b in endothelial cell function and their relevance to vascular diseases

Liangju Chen¹,Ming Yang¹,Yan Chen¹,Huaqin Sun¹,Wenming Xu^1,2

1. Joint Laboratory for Reproductive Medicine, SCU-CUHK; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education; West China Second University Hospital, Sichuan University, Chengdu 610041, China;
2. Department of Obstetric & Gynecologic Disease, West China Second University Hospital, Sichuan University, Chengdu 610041, China

Received:2014-08-29 Online:2015-02-20 Published:2015-01-19

摘要/Abstract

摘要： 微小RNA(MicroRNA, miRNA)是长度为22个核苷酸的小片段非编码RNA,作为RNA干扰的参与者之一,其通过在转录后水平调节各种基因的表达,进而对细胞的生命活动产生广泛影响。miR-15b是miR-15/16家族一员,是一类在机体各系统、特别是血管内皮系统广泛表达的微小RNA,主要影响细胞的增殖、凋亡、侵袭、成管等行为。文章主要对miR-15b及相关家族成员在各类细胞、特别是血管内皮细胞的生物学行为、作用机制及miR-15b在心血管相关疾病的发生、发展及预后等过程中的作用进行了详细阐述。同时,文章对miR-15b相关家族成员在以胎盘内皮发育异常为病理基础的妊娠期高血压疾病如子痫前期的发病机制中的作用进行了探讨。

关键词: miR-15b, 增殖, 侵袭, 肿瘤, 子痫前期

Abstract: MicroRNAs (miRNAs) are noncoding RNAs with a short length of about 22 nucleotides. As major modulators participating in RNA interference, they affect cellular behaviors by regulating the expression of diverse genes at post-transcriptional levels. miR-15b is a member of the miR-15/16 family, which is broadly expressed in major tissues and specially enriched in the endovascular system of human beings. miR-15/16 affects cellular proliferation, apoptosis, invasion and angiogenesis. In this review, we summarize the role and the underlying mechanism of miR-15b as well as other miR-15/16 family members in different cells, especially in endothelial cells. We focus on the diverse roles of miR-15b in the occurrence, progression and prognosis of vascular diseases, with particular emphasis on preeclampsia, a hypertensive disorder related to endovascular dysfunction in the placenta.

Key words: miR-15b, proliferation, invasion, tumor, preeclampsia

陈良榉,杨明,陈艳,孙华钦,许文明. miR-15b在内皮细胞的功能及其与血管相关性疾病的关系[J]. 遗传, 2015, 37(2): 121-127.

Liangju Chen,Ming Yang,Yan Chen,Huaqin Sun,Wenming Xu. Roles of miR-15b in endothelial cell function and their relevance to vascular diseases[J]. HEREDITAS(Beijing), 2015, 37(2): 121-127.

参考文献

[1] Liu XH, Fortin K, Mourelatos Z. MicroRNAs: biogenesis and molecular functions. Brain Pathol , 2008, 18(1): 113-121.
[2] Brennecke J, Stark A, Russell RB, Cohen SM. Principles of microRNA-target recognition. PLoS Biol , 2005, 3(3): e85.
[3] Wang WX, Wilfred BR, Xie K, Jennings MH, Hu YH, Stromberg AJ, Nelson PT. Individual microRNAs (miRNAs) display distinct mRNA targeting "rules". RNA Biol , 2010, 7(3): 373-380.
[4] Kiriakidou M, Nelson PT, Kouranov A, Fitziev P, Bouyioukos C, Mourelatos Z, Hatzigeorgiou A. A combined computational-experimental approach predicts human microRNA targets. Genes Dev , 2004, 18(10): 1165-1178.
[5] Griffiths-Jones S. The microRNA registry. Nucleic Acids Res , 2004, 32(Database issue): D109-D111.
[6] Finnerty JR, Wang WX, Hébert SS, Wilfred BR, Mao G, Nelson PT. The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases. J Mol Biol , 2010, 402(3): 491-509.
[7] Baskerville S, Bartel DP. Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA , 2005, 11(3): 241-247.
[8] Shingara J, Keiger K, Shelton J, Laosinchai-Wolf W, Powers P, Conrad R, Brown D, Labourier E. An optimized isolation and labeling platform for accurate microRNA expression profiling. RNA , 2005, 11(9): 1461-1470.
[9] Bruchova H, Yoon D, Agarwal AM, Mendell J, Prchal JT. Regulated expression of microRNAs in normal and polycythemia vera erythropoiesis. Exp Hematol , 2007, 35(11): 1657-1667.
[10] Choong ML, Yang HH, McNiece I. MicroRNA expression profiling during human cord blood-derived CD34 cell erythropoiesis. Exp Hematol , 2007, 35(4): 551-564.
[11] Yang GH, Wang F, Yu J, Wang XS, Yuan JY, Zhang JW. MicroRNAs are involved in erythroid differentiation control. J Cell Biochem , 2009, 107(3): 548-556.
[12] Nelson PT, Baldwin DA, Kloosterman WP, Kauppinen S, Plasterk RH, Mourelatos Z. RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. RNA , 2006, 12(2): 187-191.
[13] Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR. Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biol , 2004, 5(9): R68.
[14] Martello G, Rosato A, Ferrari F, Manfrin A, Cordenonsi M, Dupont S, Enzo E, Guzzardo V, Rondina M, Spruce T, Parenti AR, Daidone MG, Bicciato S, Piccolo S. A microRNA targeting dicer for metastasis control. Cell , 2010, 141(7): 1195-1207.
[15] Wang WX, Wilfred BR, Hu Y, Stromberg AJ, Nelson PT. Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes. RNA , 2010, 16(2): 394-404.
[16] Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T. Identification of tissue-specific microRNAs from mouse. Curr Biol , 2002, 12(9): 735-739.
[17] Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ. Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res , 2003, 1(12): 882-891.
[18] http: //www. mirbase. org/cgi-bin/mirna_entry. pl?acc= I0000438. 20140330.
[19] Möröy T, Geisen C. Cyclin E. Int J Biochem Cell Biol , 2004, 36(8): 1424-1439.
[20] Xia H, Qi Y, Ng SS, Chen X, Chen S, Fang M, Li D, Zhao Y, Ge R, Li G, Chen Y, He ML, Kung HF, Lai L, Lin MC. MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells. Biochem Biophys Res Commun , 2009, 380(2): 205-210.
[21] Bueno MJ, Gómez de Cedrón M, Laresgoiti U, Fernández- iqueras J, Zubiaga AM, Malumbres M. Multiple E2F-indced microRNAs prevent replicative stress in response to mitogenic signaling. Mol Cell Biol , 2010, 30(12): 2983-2995.
[22] Sun G, Shi L, Yan SS, Wan ZQ, Jiang N, Fu LS, Li M, Guo J. MiR-15b targets cyclin D1 to regulate proliferation and apoptosis in glioma cells. Biomed Res Int , 2014, 201

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

miR-15b在内皮细胞的功能及其与血管相关性疾病的关系

Roles of miR-15b in endothelial cell function and their relevance to vascular diseases

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	孙清玙, 周阳, 杜丽娟, 张梦珂, 王家乐, 任媛媛, 刘芳. 巨噬细胞相关基因与非小细胞肺癌预后和肿瘤微环境的分析[J]. 遗传, 2023, 45(8): 684-699.
[2]	严程浩, 白韦钰, 张智猛, 沈俊岭, 王友军, 孙建伟. STIM1在肿瘤发生及转移中的研究进展[J]. 遗传, 2023, 45(5): 395-408.
[3]	吴玲玲, 张小玉, 李晓, 靳建军, 杨公社, 史新娥. miR-196b-5p促进成肌细胞增殖分化[J]. 遗传, 2023, 45(5): 435-446.
[4]	马春辉, 胡海旭, 张丽娟, 刘毅, 刘天懿. 用于循环肿瘤细胞定量分析的CK19数字PCR检测方法的建立及性能验证[J]. 遗传, 2023, 45(3): 250-260.
[5]	常栋, 刘享享, 刘睿, 孙建伟. FSCN1在乳腺癌发生发展中的作用及其调控机制[J]. 遗传, 2023, 45(2): 115-127.
[6]	郝庆刚, 孙凤桂, 严程浩, 孙建伟. MT1-MMP在肿瘤转移中的研究进展[J]. 遗传, 2022, 44(9): 745-755.
[7]	赵岩, 王晨鑫, 杨天明, 李春爽, 张丽宏, 杜冬妮, 王若曦, 王静, 魏民, 巴雪青. DNA氧化损伤8-羟鸟嘌呤与肿瘤的发生发展[J]. 遗传, 2022, 44(6): 466-477.
[8]	赵欢, 周斌. 胰岛beta细胞再生研究进展[J]. 遗传, 2022, 44(5): 370-382.
[9]	范志露, 杨荔艳, 张娜, 冯丹, 郭静, 常晨, 苑青, 蔡岩, 张钰, 魏文强, 王明荣, 郝佳洁. NEFL通过激活EGFR/AKT/S6信号通路促进食管鳞癌细胞的侵袭迁移[J]. 遗传, 2022, 44(4): 322-334.
[10]	王翠玲, 刘信燚, 王亚会, 张争, 王治东, 周钢桥. MCM2通过抑制p53信号通路促进胆管癌细胞的增殖、迁移和侵袭[J]. 遗传, 2022, 44(3): 230-244.
[11]	唐湘薇, 楚丹, 颜赛娜, 尹艳飞, 卞桥, 翁波, 陈斌, 冉茂良. miR-191靶向BDNF基因通过激活PI3K/AKT信号通路促进猪未成熟支持细胞增殖[J]. 遗传, 2021, 43(7): 680-693.
[12]	寇艳妮, 岑山, 李晓宇. LINE-1在肿瘤早期诊断和治疗中的研究与应用[J]. 遗传, 2021, 43(6): 571-579.
[13]	王卓, 申笑涵, 施奇惠. 单细胞基因组测序技术新进展及其在生物医学中的应用[J]. 遗传, 2021, 43(2): 108-117.
[14]	刘倩, 李春燕. 增强子的鉴定及其在肿瘤研究中的应用[J]. 遗传, 2020, 42(9): 817-831.
[15]	赵利楠, 王娜, 杨国良, 苏现斌, 韩泽广. 基于单细胞靶向测序探究基因碱基突变的方法[J]. 遗传, 2020, 42(7): 703-712.