miR-15b在内皮细胞的功能及其与血管相关性疾病的关系

doi:10.16288/j.yczz.14-288

遗传 ›› 2015, Vol. 37 ›› Issue (2): 121-127.doi: 10.16288/j.yczz.14-288

miR-15b在内皮细胞的功能及其与血管相关性疾病的关系

陈良榉¹,杨明¹,陈艳¹,孙华钦¹,许文明^1,2

1. 四川大学华西第二医院,四川大学-香港中文大学生殖医学联合实验室,教育部出生缺陷与相关妇儿疾病重点实验室,成都610041;
2. 四川大学,四川大学华西第二医院妇产科,成都 610041

收稿日期:2014-08-29 出版日期:2015-02-20 发布日期:2015-01-19
通讯作者: 许文明,副研究员,硕士生导师,研究方向：生殖生物学与生殖医学。E-mail: xuwenming1973@163.com
作者简介:陈良榉,硕士研究生,专业方向：出生缺陷。Tel：028-85502290;E-mail: 248698579@qq.com
基金资助:
国家重点基础研究计划(973计划)(编号：2012CB944903)和新世纪人才计划项目(编号：NCET-12-0382)资助

Roles of miR-15b in endothelial cell function and their relevance to vascular diseases

Liangju Chen¹,Ming Yang¹,Yan Chen¹,Huaqin Sun¹,Wenming Xu^1,2

1. Joint Laboratory for Reproductive Medicine, SCU-CUHK; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education; West China Second University Hospital, Sichuan University, Chengdu 610041, China;
2. Department of Obstetric & Gynecologic Disease, West China Second University Hospital, Sichuan University, Chengdu 610041, China

Received:2014-08-29 Online:2015-02-20 Published:2015-01-19

摘要/Abstract

摘要： 微小RNA(MicroRNA, miRNA)是长度为22个核苷酸的小片段非编码RNA,作为RNA干扰的参与者之一,其通过在转录后水平调节各种基因的表达,进而对细胞的生命活动产生广泛影响。miR-15b是miR-15/16家族一员,是一类在机体各系统、特别是血管内皮系统广泛表达的微小RNA,主要影响细胞的增殖、凋亡、侵袭、成管等行为。文章主要对miR-15b及相关家族成员在各类细胞、特别是血管内皮细胞的生物学行为、作用机制及miR-15b在心血管相关疾病的发生、发展及预后等过程中的作用进行了详细阐述。同时,文章对miR-15b相关家族成员在以胎盘内皮发育异常为病理基础的妊娠期高血压疾病如子痫前期的发病机制中的作用进行了探讨。

关键词: miR-15b, 增殖, 侵袭, 肿瘤, 子痫前期

Abstract: MicroRNAs (miRNAs) are noncoding RNAs with a short length of about 22 nucleotides. As major modulators participating in RNA interference, they affect cellular behaviors by regulating the expression of diverse genes at post-transcriptional levels. miR-15b is a member of the miR-15/16 family, which is broadly expressed in major tissues and specially enriched in the endovascular system of human beings. miR-15/16 affects cellular proliferation, apoptosis, invasion and angiogenesis. In this review, we summarize the role and the underlying mechanism of miR-15b as well as other miR-15/16 family members in different cells, especially in endothelial cells. We focus on the diverse roles of miR-15b in the occurrence, progression and prognosis of vascular diseases, with particular emphasis on preeclampsia, a hypertensive disorder related to endovascular dysfunction in the placenta.

Key words: miR-15b, proliferation, invasion, tumor, preeclampsia

陈良榉,杨明,陈艳,孙华钦,许文明. miR-15b在内皮细胞的功能及其与血管相关性疾病的关系[J]. 遗传, 2015, 37(2): 121-127.

Liangju Chen,Ming Yang,Yan Chen,Huaqin Sun,Wenming Xu. Roles of miR-15b in endothelial cell function and their relevance to vascular diseases[J]. HEREDITAS(Beijing), 2015, 37(2): 121-127.

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miR-15b在内皮细胞的功能及其与血管相关性疾病的关系

Roles of miR-15b in endothelial cell function and their relevance to vascular diseases

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