遗传 ›› 2015, Vol. 37 ›› Issue (10): 974-982.doi: 10.16288/j.yczz.15-109
璩良, 李华善, 姜运涵, 董春升
收稿日期:
2015-03-16
出版日期:
2015-10-20
发布日期:
2015-10-20
通讯作者:
董春升,副教授,研究方向:免疫学。 E-mail:chunshengdong@suda.edu.cn
作者简介:
璩良,本科生,专业方向:生物技术(免疫工程)。E-mail: quliangsuda@163.com
基金资助:
Liang Qu, Huashan Li, Yunhan Jiang, Chunsheng Dong
Received:
2015-03-16
Online:
2015-10-20
Published:
2015-10-20
摘要: CRISPR/Cas系统是广泛存在于细菌和古生菌中的适应性免疫系统,用来抵抗外来病毒或质粒的入侵。近几年,由Ⅱ型CRISPR/Cas适应性免疫系统改造而来的CRISPR/ Cas9基因组编辑技术蓬勃发展,被广泛地应用于生命科学研究的各个领域,并取得了革命性的变化。文章主要综述了CRISPR/Cas9基因组编辑技术的起源与发展及在生命科学各研究领域的应用,重点介绍了该系统在人类疾病基因治疗方面的最新应用及脱靶效应,以期为相关领域的科研人员提供参考。
璩良, 李华善, 姜运涵, 董春升. CRISPR/Cas9系统的分子机制及其在人类疾病基因治疗中的应用[J]. 遗传, 2015, 37(10): 974-982.
Liang Qu, Huashan Li, Yunhan Jiang, Chunsheng Dong. The molecular mechanism of CRISPR/Cas9 system and its application in gene therapy of human diseases[J]. HEREDITAS(Beijing), 2015, 37(10): 974-982.
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