泛素-蛋白酶体途径在精子生成中的作用

doi:10.16288/j.yczz.16-120

遗传 ›› 2016, Vol. 38 ›› Issue (9): 791-800.doi: 10.16288/j.yczz.16-120

泛素-蛋白酶体途径在精子生成中的作用

董莲花^{1, 2}, 冉茂良^{1, 2}, 李智^{1, 2}, 彭馥芝^{1, 2}, 陈斌^{1, 2}

1. 湖南农业大学动物科学技术学院,长沙 410128;
2. 畜禽遗传改良湖南省重点实验室,长沙 410128

收稿日期:2016-04-05 出版日期:2016-09-20 发布日期:2016-09-20
通讯作者: 陈斌,博士,教授,博士生导师,研究方向：动物遗传育种。E-mail: chenbin7586@126.com
作者简介:董莲花,硕士研究生,专业方向：动物遗传育种。E-mail: donglianhua013@126.com
基金资助:
国家现代农业产业技术体系建设专项资金(编号：CARS-36)

The role of ubiquitin-proteasome pathway in spermatogenesis

Lianhua Dong^{1, 2}, Maoliang Ran^{1, 2}, Zhi Li^{1, 2}, Fuzhi Peng^{1, 2}, Bin Chen^{1, 2}

1. College of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China;
2. Hunan Provincial Key Laboratory for Genetic Improvement of Domestic Animal, Changsha 410128, China

Received:2016-04-05 Online:2016-09-20 Published:2016-09-20
Supported by:
[Supported by China Agriculture Research System (No; CARS-36)]

摘要/Abstract

摘要： 泛素-蛋白酶体途径(Ubiquitin-proteasome pathway,UPP)是真核细胞内蛋白质主要降解途径,通过调节蛋白质相互作用、蛋白活性、蛋白定位及信号转导,进而在细胞周期进程、细胞凋亡、应激反应及机体生长发育等过程发挥重要作用。研究表明,UPP在人和动物精子生成中的顶体生物合成及精子尾部形成过程起着关键的调控作用,精子变态过程中UPP调控异常导致精子畸形及精子活力降低,并引发少精子症、不育及睾丸肿瘤等生殖系统疾病。本文综述了UPP在动物精子生成过程中的信号传导及调节机制,以期为后续相关研究提供参考。

关键词: 泛素-蛋白酶体途径, 泛素化, 精子发生

Abstract: Ubiquitin-proteasome pathway (UPP) is the main pathway of protein degradation in eukaryotic cells. The UPP plays very important roles in cell cycle progression, apoptosis, stress response and growth and development through regulating protein interaction, protein activity, protein localization and signal transduction. Previous studies have shown that the UPP is essential for regulating acrosome and tail biogenesis during spermatogenesis in human and animals. The dysregulation of UPP during spermatogenesis results in sperm deformity and reduced sperm motility and leads to reproductive system diseases such as oligospermatism, infertility and testicular tumors. In this review, we summarized the signal transduction and regulation mechanism of UPP in spermatogenesis, which may provide references for future studies.

Key words: ubiquitin-proteasome pathway, ubiquitination, spermatogenesis

董莲花, 冉茂良, 李智, 彭馥芝, 陈斌. 泛素-蛋白酶体途径在精子生成中的作用[J]. 遗传, 2016, 38(9): 791-800.

Lianhua Dong, Maoliang Ran, Zhi Li, Fuzhi Peng, Bin Chen. The role of ubiquitin-proteasome pathway in spermatogenesis[J]. Hereditas(Beijing), 2016, 38(9): 791-800.

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泛素-蛋白酶体途径在精子生成中的作用

The role of ubiquitin-proteasome pathway in spermatogenesis

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