植物环状RNA研究进展

doi:10.16288/j.yczz.18-009

遗传 ›› 2018, Vol. 40 ›› Issue (6): 467-477.doi: 10.16288/j.yczz.18-009

植物环状RNA研究进展

骆甲,王型力,孙志超,吴迪,张玮,王正加()

浙江农林大学,亚热带森林培育国家重点实验室培育基地,杭州 311300

收稿日期:2018-01-08 修回日期:2018-03-21 出版日期:2018-06-20 发布日期:2018-05-31
作者简介:骆甲,硕士研究生,专业方向：林木遗传育种。E-mail: jlocke@163.com
基金资助:
国家自然科学基金项目(31570666);国家高技术研究发展计划项目( 863项目)(2013AA102605);浙江省自然科学基金杰出青年项目(LR14C160002);浙江省农业新品种选育重大科技专项资助(2016C02052)

Progress in circular RNAs of plants

Jia Luo,Xingli Wang,Zhichao Sun,Di Wu,Wei Zhang,Zhengjia Wang()

Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China

Received:2018-01-08 Revised:2018-03-21 Published:2018-06-20 Online:2018-05-31
Supported by:
Supported by the National Natural Science Foundation of China(31570666);the National High-Tech Research and Development Program of China (863 Program)(2013AA102605);Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars(LR14C160002);Zhejiang Provincial New Varieties Breeding Major Agricultural Science and Technology Projects(2016C02052)

摘要/Abstract

摘要：

环状RNA (circRNA)是一类由mRNA前体经反向可变剪切而来的共价闭合且保守的单链转录本,通过miRNA海绵功能、干扰可变剪切、结合蛋白等方式调控源基因及线性mRNA的表达。测序结果显示,circRNA广泛存在于不同的植物体内,通过细胞类型特异性表达以及组织特异性表达参与花发育、果实成熟、逆境响应等多个生命过程,在植物发育过程中发挥着重要作用。本文综述了植物circRNA的形成机制、鉴定方法、数据库、表达模式以及潜在的生物学功能,通过与动物相关研究结果的比较,概括了植物circRNA的结构特征和调控潜能,以期为植物circRNA研究提供参考。

关键词: 植物circRNA, 数据库, 调控, 功能

Abstract:

Circular RNAs (circRNAs) are covalently closed, conserved single-stranded transcripts that are produced from precursor mRNA (pre-mRNA) back-splicing. They could function as microRNA sponges, interfere with splicing and bind to protein to regulate the expression of parental genes and linear mRNAs. Next-generation RNA sequencing (RNA-seq) has recently shown that the expression of circRNAs is widespread in plants. circRNAs participate in multiple biological processes such as floral development, fruit ripening, and biotic and abiotic stress responses by cell type-specific and tissue-specific expression patterns, indicating that they may play an important role in plant development. In this review, we summarize the current knowledge of plant circRNAs in recent years, including the biogenesis, detection, databases, expression pattern, and potential functions in comparison with animal results to provide new insights for functional research interests of circRNAs in the future.

Key words: plant circRNA, database, regulation, function

骆甲,王型力,孙志超,吴迪,张玮,王正加. 植物环状RNA研究进展[J]. 遗传, 2018, 40(6): 467-477.

Jia Luo,Xingli Wang,Zhichao Sun,Di Wu,Wei Zhang,Zhengjia Wang. Progress in circular RNAs of plants[J]. Hereditas(Beijing), 2018, 40(6): 467-477.

参考文献

[1]	Batista PJ, Chang HY . Long noncoding RNAs: Cellular address codes in development and disease. Cell, 2013,152(6):1298-1307.
[2]	Guttman M, Rinn JL . Modular regulatory principles of large non-coding RNAs. Nature, 2012,482(7385):339-346.
[3]	Ulitsky I , Bartel DP. lincRNAs: genomics, evolution, and mechanisms. Cell, 2013,154(1):26-46.
[4]	Baek D, Villén J, Shin C, Camargo FD, Gygi SP, Bartel DP . The impact of microRNAs on protein output. Nature, 2008,455(7209):64-71.
[5]	Ebert MS, Neilson JR, Sharp PA . MicroRNA sponges: Competitive inhibitors of small RNAs in mammalian cells. Nat Methods, 2007,4(9):721-726.
[6]	Ebert MS, Sharp PA . Emerging roles for natural microRNA sponges. Curr Biol, 2010,20(19):R858-861.
[7]	Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M, Tramontano A, Bozzoni I . A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell, 2011,147(2):358-369.
[8]	Lu C, Huang YH . Progress in long non-coding RNAs in animals. Hereditas (Beijing), 2017,39(11):1054-1065.
[8]	路畅, 黄银花 . 动物长链非编码RNA研究进展. 遗传, 2017,39(11):1054-1065.
[9]	Lasda E, Parker R . Circular RNAs: diversity of form and function. RNA, 2014,20(12):1829-1842.
[10]	Ashwal-Fluss R, Meyer M, Pamudurti NR, Ivanov A, Bartok O, Hanan M, Evantal N, Memczak S, Rajewsky N , Kadener S. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell, 2014,56(1):55-66.
[11]	Starke S, Jost I, Rossbach O, Schneider T, Schreiner S, Hung LH, Bindereif A . Exon circularization requires canonical splice signals. Cell Rep, 2015,10(1):103-111.
[12]	Wang Y, Wang ZF . Efficient backsplicing produces translatable circular mRNAs. RNA, 2015,21(2):172-179.
[13]	Zhang XO, Wang HB, Zhang Y, Lu X, Chen LL, Yang L . Complementary sequence-mediated exon circularization. Cell, 2014,159(1):134-147.
[14]	Liang D, Wilusz JE . Short intronic repeat sequences facilitate circular RNA production. Genes Dev, 2014,28(20):2233-2247.
[15]	Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ . The RNA binding protein quaking regulates formation of circRNAs. Cell, 2015,160(6):1125-1134.
[16]	Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, Le

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

植物环状RNA研究进展

Progress in circular RNAs of plants

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics