KRAB型锌指蛋白在高等脊椎动物胚胎发育和肿瘤发生、发展中的调控功能

doi:10.3724/SP.J.1005.2010.00431

遗传 ›› 2010, Vol. 32 ›› Issue (5): 431-436.doi: 10.3724/SP.J.1005.2010.00431

KRAB型锌指蛋白在高等脊椎动物胚胎发育和肿瘤发生、发展中的调控功能

马占福^{1, 2}, 杨冬², 贺福初², 姜颖²

1. 北京工业大学生命科学与生物工程学院, 北京 100022;
2. 蛋白质组学国家重点实室, 北京蛋白质组研究中心, 军事医学科学院放射与辐射医学研究所, 北京 102206

收稿日期:2009-09-27 修回日期:2009-12-07 出版日期:2010-05-20 发布日期:2010-05-15
通讯作者: 姜颖 E-mail:jiangying304@hotmail.com
基金资助:
国家重点基础研究发展规划(973计划)项目(编号：2006CB910801), 国家高技术研究发展计划项目(863计划)(编号：2006AA02A308)和蛋白质组学国家重点实验室课题(编号：SKLP-Y200801)资助

Review for the regulatory functions of KRAB zinc finger proteins in embryonic development and tumorgenesis of higher vertebrates

MA Zhan-Fu^{1, 2}, YANG Dong², HE Fu-Chu², JIANG Ying²

1. College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100022, China;
2. State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China

Received:2009-09-27 Revised:2009-12-07 Online:2010-05-20 Published:2010-05-15
Contact: JIANG Ying E-mail:jiangying304@hotmail.com

摘要/Abstract

摘要：

KRAB型锌指蛋白(KRAB-ZFPs)最早出现于四足类脊椎动物, 且进化非常迅速, 是人类基因组编码的最大转录因子家族。尽管当前对此家族蛋白发挥调控功能的分子机制已有较为深入的研究, 但关于此家族蛋白所具备的高等脊椎动物特有的调控功能目前尚无全面系统的认识。文章对KRAB型锌指蛋白在高等脊椎动物的胚胎发育及肿瘤发生、发展中发挥的调控功能进行综述, 以期丰富对该家族蛋白在不同生理、病理过程中调控功能的认识, 为今后更深入的理论和应用研究打下坚实基础。

关键词: KRAB, 胚胎发育, 肿瘤, 转录调控

Abstract:

KRAB-containing zinc-finger proteins (KRAB-ZFPs) first arose in the tetrapod vertebrates, and evolved quickly. Till Homo sapiens, they have become the largest family of transcription factors. Despite the molecular mechanism of transcription regulation by KRAB-ZFPs has been clarified in some degree, the higher-vertebrate-specific biological functions of the KRAB-ZFP family are still largely unknown. This review focused on the important regulatory functions of the KRAB-ZFP in embryonic development and tumorgenesis, which will benefit to the comprehensive understanding of biological roles of KRAB-ZFP in different physiological and pathological states. All of the systematic information will facilitate the further theoretical and applied studies of KRAB-ZFPs.

Key words: KRAB, embryonic development, tumor, transcription regulation

马占福，杨冬，贺福初，姜颖. KRAB型锌指蛋白在高等脊椎动物胚胎发育和肿瘤发生、发展中的调控功能[J]. 遗传, 2010, 32(5): 431-436.

MA Tie-Fu, YANG Dong, HE Fu-Chu, JIANG Ying. Review for the regulatory functions of KRAB zinc finger proteins in embryonic development and tumorgenesis of higher vertebrates[J]. HEREDITAS, 2010, 32(5): 431-436.

参考文献

[1] 杨冬, 姜颖, 贺福初. KAP-1, 转录调控中的一个桥梁分子. 遗传, 2007, 29(2): 131–136.

[2] 田春艳, 张令强, 贺福初. KRAB型锌指蛋白(KZNF)的研究进展. 遗传, 2006, 28(11): 1451–1456.

[3] Emerson RO, Thomas JH, Adaptive evolution in zinc fin-ger transcription factors. PLoS Genet, 2009, 5(1): 1-12.

[4] Ferguson-Smith AC, Surani MA. Imprinting and the epi-genetic asymmetry between parental genomes. Science, 2001, 293(5532): 1086–1089.

[5] Reik W, Walter J. Genomic imprinting: parental influence on the genome. Nat Rev Genet, 2001, 2(1): 21–32.

[6] Verona RI, Mann MR, Bartolomei MS. Genomic imprint-ing: intricacies of epigenetic regulation in clusters. Annu Rev Cell Dev Biol, 2003, 19: 237–259.

[7] Hirasawa R, Feil R. A KRAB domain zinc finger protein in imprinting and disease. Dev Cell, 2008, 15(4): 487–488.

[8] Li X, Ito M, Zhou F, Youngson N, Zuo X, Leder P, Fergu-son-Smith AC. A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev Cell, 2008, 15(4): 547–557.

[9] Wiznerowicz M, Jakobsson J, Szulc J, Liao S, Quazzola A, Beermann F, Aebischer P, Trono D. The Krup-pel-associated box repressor domain can trigger de novo promoter methylation during mouse early embryogenesis. J Biol Chem, 2007, 282(47): 34535–34541.

[10] Ellis J, Hotta A, Rastegar M. Retrovirus silencing by an epigenetic TRIM. Cell, 2007, 131(1): 13–14.

[11] Teich NM, Weiss RA, Martin GR, Lowy DR. Virus infec-tion of murine teratocarcinoma stem cell lines. Cell, 1977, 12(4): 973–982.

[12] Wolf D, Goff SP. TRIM28 mediates primer binding site-targeted silencing of murine leukemia virus in em-bryonic cells. Cell, 2007, 131(1): 46–57.

[13] Wolf D, Goff SP. Embryonic stem cells use ZFP809 to silence retroviral DNAs. Nature, 2009, 458(7242): 1201–1204.

[14] Ninomiya H, Elinson RP, Winklbauer R. Antero-posterior tissue polarity links mesoderm convergent extension to axial patterning. Nature, 2004, 430(6997): 364–367.

[15] García-García MJ, Shibata M, Anderson KV. Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development, 2008, 135(18): 3053–3062.

[16] Li Y, Yang D, Bai Y, Mo X, Huang W, Yuan W, Yin Z, Deng Y, Murashko O, Wang Y, Fan X, Zhu C, Ocorr K, Bodmer R, Wu X. ZNF418, a novel human KRAB/C2H2 zinc finger protein, suppresses MAPK signaling pathway. Mol Cell Biochem, 2008, 310(1-2): 141–151.

[17] Xiang Z, Yuan W, Luo N, Wang Y, Tan K, Deng Y, Zhou X, Zhu C, Li Y, Liu M, Wu X, Li Y. A novel human zinc fin-ger protein ZNF540 interacts with MVP and inhibits tran-scriptional activities of the ERK signal pathway. Biochem Biophys Res Commun, 2006, 347(1): 288–296.

[18] Cao L, Wang Z, Zhu C, Zhao Y, Yuan W, Li J, Wang Y, Ying Z, Li Y, Yu W, Wu X, Liu M. ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway. Biochem Biophys Res Commun, 2005, 333(4): 1050–1059.

[19] Zaret KS. Regulatory phases of early liver development: Paradigms of organogenesis. Nat Rev Genet, 2002, 3(7): 499–512.

[20] Duncan SA. Mechanisms controlling early development of the liver. Mech Dev, 2003, 120(1): 19–33.

[21] Ying W, Jiang Y, Guo L, Hao Y, Zhang Y, Wu S, Zhong F, Wang J, Shi R, Li D, Wan P, Li X, Wei H, Li J, Wang Z, Xue X, Cai Y, Zhu Y, Qian X, He F. A dataset of human fetal liver proteome identified by subcellular fractionation and multiple protein separation and identification tech-nology. Mol Cell Proteomics, 2006, 5(9): 1703–1707.

[22] Jiang Y, Ying W, Wu S, Chen M, Guan W, Yang D, Song Y, Liu X, Li J, Hao Y, Sun A, Geng C, Li H, Mi W, Zhang Y, Zhang J, Chen X, Li L, Gong Y, Li T, Ma J, Li D, Yuan X, Zhang, X, Xue X, Zhu Y, Qian X, He F, Zhong F, Shen H, Lin C, Lu H, Wei L, Cao J, Yun D, Gao M, Fan H, Cheng G, Yu Y, Xie L, Wang H, Yang P. Y, Shi L, Tong W, Li X, Wang Y, Liu S, Sheng Q, Zeng R, Sun Y, Xu Y, Cai J, He P, Gao H, Zhao, X. H, Tan Y, Yan H, YangY, Huang J, Han, Z. G, He Q, Chen P, Liang S, Zhao M, Mao X, Yu H, Cao Z, Li Y, Dai, W, Jiang H, Wang D, Zheng J, Xue G, Tang Y, Cheng J, Liu Y, Wang X, Jia J, An D, Wang Z, Li Q, Cui T. First insight into human liver proteome from PROTEOMESKY-LIVERHu 1.0, a publicly-available data-base. J Proteome Res, 2009, 9(1): 79-94.

[23] Chen CF, Li S, Chen Y, Chen PL, Sharp ZD, Lee WH. The nuclear localization sequences of the BRCA1 protein in-teract with the importin-alpha subunit of the nuclear transport signal receptor. J Biol Chem, 1996, 271(51): 32863–32868.

[24] Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH. Sequence-specific transcriptional corepres-sor function for BRCA1 through a novel zinc finger pro-tein, ZBRK1. Mol Cell, 2000, 6(4): 757–768.

[25] Laptenko O, Prives C. Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ, 2006, 13(6): 951–961.

[26] Tian C, Xing G, Xie P, Lu K, Nie J, Wang J, Li L, Gao M, Zhang L, He F. KRAB-type zinc-finger protein Apak spe-cifically regulates p53-dependent apoptosis. Nat Cell Biol, 2009, 11(5): 580–591.

[27] Ziv Y, Bielopolski D, Galanty Y, Lukas C, Taya Y, Schultz DC, Lukas J, Bekker-Jensen S, Bartek J, Shiloh Y. Chro-matin relaxation in response to DNA double-strand breaks is modulated by a novel ATM and KAP-1 de-pendent pathway. Nat Cell Biol, 2006, 8(8): 870–876.

[28] Goodarzi AA, Noon AT, Deckbar D, Ziv Y, Shiloh Y, Löbrich M, Jeggo PA. ATM signaling facilitates repair of DNA double-strand breaks associated with heterochro-matin. Mol Cell, 2008, 31(2): 167–177.

[29] Huang C, Jia Y, Yang S, Chen B, Sun H, Shen F, Wang Y. Characterization of ZNF23, a KRAB-containing protein that is down regulated in human cancers and inhibits cell cycle progression. Exp Cell Res, 2007, 313(2): 254–263.

[30] Huang C, Yang S, Ge R, Sun H, Shen F, Wang Y. ZNF23 induces apoptosis in human ovarian cancer cells. Cancer Lett, 2008, 266(2): 135–143.

[31] Yang Z, Wen HJ, Minhas V, Wood C. The zinc finger DNA-binding domain of K-RBP plays an important role in regulating Kaposi’s sarcoma-associated herpesvirus RTA-mediated gene expression. Virology, 2009, 391(2): 221–231.

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KRAB型锌指蛋白在高等脊椎动物胚胎发育和肿瘤发生、发展中的调控功能

Review for the regulatory functions of KRAB zinc finger proteins in embryonic development and tumorgenesis of higher vertebrates

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