KRAB型锌指蛋白在高等脊椎动物胚胎发育和肿瘤发生、发展中的调控功能

doi:10.3724/SP.J.1005.2010.00431

遗传 ›› 2010, Vol. 32 ›› Issue (5): 431-436.doi: 10.3724/SP.J.1005.2010.00431

KRAB型锌指蛋白在高等脊椎动物胚胎发育和肿瘤发生、发展中的调控功能

马占福^{1, 2}, 杨冬², 贺福初², 姜颖²

1. 北京工业大学生命科学与生物工程学院, 北京 100022;
2. 蛋白质组学国家重点实室, 北京蛋白质组研究中心, 军事医学科学院放射与辐射医学研究所, 北京 102206

收稿日期:2009-09-27 修回日期:2009-12-07 出版日期:2010-05-20 发布日期:2010-05-15
通讯作者: 姜颖 E-mail:jiangying304@hotmail.com
基金资助:
国家重点基础研究发展规划(973计划)项目(编号：2006CB910801), 国家高技术研究发展计划项目(863计划)(编号：2006AA02A308)和蛋白质组学国家重点实验室课题(编号：SKLP-Y200801)资助

Review for the regulatory functions of KRAB zinc finger proteins in embryonic development and tumorgenesis of higher vertebrates

MA Zhan-Fu^{1, 2}, YANG Dong², HE Fu-Chu², JIANG Ying²

1. College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100022, China;
2. State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China

Received:2009-09-27 Revised:2009-12-07 Online:2010-05-20 Published:2010-05-15
Contact: JIANG Ying E-mail:jiangying304@hotmail.com

摘要/Abstract

摘要：

KRAB型锌指蛋白(KRAB-ZFPs)最早出现于四足类脊椎动物, 且进化非常迅速, 是人类基因组编码的最大转录因子家族。尽管当前对此家族蛋白发挥调控功能的分子机制已有较为深入的研究, 但关于此家族蛋白所具备的高等脊椎动物特有的调控功能目前尚无全面系统的认识。文章对KRAB型锌指蛋白在高等脊椎动物的胚胎发育及肿瘤发生、发展中发挥的调控功能进行综述, 以期丰富对该家族蛋白在不同生理、病理过程中调控功能的认识, 为今后更深入的理论和应用研究打下坚实基础。

关键词: KRAB, 胚胎发育, 肿瘤, 转录调控

Abstract:

KRAB-containing zinc-finger proteins (KRAB-ZFPs) first arose in the tetrapod vertebrates, and evolved quickly. Till Homo sapiens, they have become the largest family of transcription factors. Despite the molecular mechanism of transcription regulation by KRAB-ZFPs has been clarified in some degree, the higher-vertebrate-specific biological functions of the KRAB-ZFP family are still largely unknown. This review focused on the important regulatory functions of the KRAB-ZFP in embryonic development and tumorgenesis, which will benefit to the comprehensive understanding of biological roles of KRAB-ZFP in different physiological and pathological states. All of the systematic information will facilitate the further theoretical and applied studies of KRAB-ZFPs.

Key words: KRAB, embryonic development, tumor, transcription regulation

马占福，杨冬，贺福初，姜颖. KRAB型锌指蛋白在高等脊椎动物胚胎发育和肿瘤发生、发展中的调控功能[J]. 遗传, 2010, 32(5): 431-436.

MA Tie-Fu, YANG Dong, HE Fu-Chu, JIANG Ying. Review for the regulatory functions of KRAB zinc finger proteins in embryonic development and tumorgenesis of higher vertebrates[J]. HEREDITAS, 2010, 32(5): 431-436.

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KRAB型锌指蛋白在高等脊椎动物胚胎发育和肿瘤发生、发展中的调控功能

Review for the regulatory functions of KRAB zinc finger proteins in embryonic development and tumorgenesis of higher vertebrates

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