MicroRNAs的分子进化与调控机制

doi:10.3724/SP.J.1005.2010.00874

遗传 ›› 2010, Vol. 32 ›› Issue (9): 874-880.doi: 10.3724/SP.J.1005.2010.00874

MicroRNAs的分子进化与调控机制

王天宇^{1, 2}, 董园园¹, 李海燕¹, 李校堃¹

1. 吉林农业大学生物反应器与药物开发教育部工程研究中心, 长春 130118; 2. 吉林农业大学生命科学学院, 长春130118

收稿日期:2009-12-31 修回日期:2010-02-24 出版日期:2010-09-20 发布日期:2010-09-20
通讯作者: 李海燕;李校堃 E-mail:hyli99@163.com;xiaokunli@163.net
基金资助:
国家高技术研究发展计划项目(863计划) (编号：2007AA100503)资助

Research and application of microRNA evolution and regulation

WANG Tian-Yu^{1, 2}, DONG Yuan-Yuan¹, LI Hai-Yan¹, LI Xiao-Kun¹

1. Engineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, Jilin Agricultural University, Changchun 130118, 2. College of Life Science, Jilin Agricultural University, Changchun 130118, China

Received:2009-12-31 Revised:2010-02-24 Online:2010-09-20 Published:2010-09-20
Contact: LI Hai-Yan; LI Xiao-Kun E-mail:hyli99@163.com;xiaokunli@163.net

摘要/Abstract

摘要： MicroRNAs(miRNAs)是一类专门调控基因表达的非编码小分子RNA，广泛参与生物发育、细胞分化、细胞凋亡等多种生命进程。miRNAs在不同种系间独立进化且在进化演变中普遍保守。文章综述了miRNAs起源、进化上的保守性及甲基化调控方面研究进展, 另外在疾病和动植物应用方面的研究也作了较为详细的阐述。

关键词: 小分子RNA, 微小RNA 进化, 甲基化

Abstract: MicroRNAs, a type of small non-coding RNA specialized in regulation of gene expression, extensively participate in biological development, cell differentiation, apoptosis, and other cellular processes. MiRNAs evolved independently in different strains and generally conserved in the process of evolution. This review summarized the origin, regulation of methylation, and evolutionary conservation of miRNAs. In addition, application of miRNAs in diseases, animals and plants was discussed.

Key words: miRNA, microRNA evolution, DNA methylation

王天宇，董园园，李海燕，李校堃. MicroRNAs的分子进化与调控机制[J]. 遗传, 2010, 32(9): 874-880.

WANG Tian-Yu, DONG Wan-Wan, LI Hai-Yan, LI Jiao-Kun. Research and application of microRNA evolution and regulation[J]. HEREDITAS, 2010, 32(9): 874-880.

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MicroRNAs的分子进化与调控机制

Research and application of microRNA evolution and regulation

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