遗传 ›› 2014, Vol. 36 ›› Issue (12): 1195-1203.doi: 10.3724/SP.J.1005.2014.1195

• 综述 • 上一篇    下一篇

高血压易感基因的分子进化

季林丹1, 2, 钱海霞3, 徐进2, 3   

  1. 1. 宁波大学医学院生物化学系, 宁波 315211;
    2. 中国科学院昆明动物研究所遗传资源与进化国家重点实验室, 昆明 650223;
    3. 宁波大学医学院预防医学系, 宁波 315211
  • 收稿日期:2014-08-20 出版日期:2014-12-20 发布日期:2014-12-20
  • 作者简介:季林丹, 博士后, 讲师, 研究方向:分子进化与疾病遗传学
  • 基金资助:

    国家自然科学基金项目(编号:81402747)和浙江省自然科学基金项目(编号:LQ13C060001)资助

The evolutionary study of susceptibility genes for essential hypertension

Lindan Ji1, 2, Haixia Qian3, Jin Xu2, 3   

  1. 1. Department of Biochemistry, School of Medicine, Ningbo University, Ningbo 315211, China;
    2. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China;
    3. Department of Preventive Medicine, School of Medicine, Ningbo University, Ningbo 315211, China
  • Received:2014-08-20 Online:2014-12-20 Published:2014-12-20

摘要:

利用家系连锁分析、候选基因法及全基因组关联研究均未能有效发现普通人群的高血压易感基因或位点。遗传学研究表明, 人类许多疾病易感性的形成与走出非洲时的环境适应性进化密切相关, 这为高血压遗传学研究提供了新思路。文章系统综述了高血压易感基因分子进化研究的理论基础和最新进展, 介绍了本研究小组运用分子进化思路在中国汉族人群高血压遗传学研究中的发现, 对未来的研究方向进行了展望, 以期为高血压和其他疾病的遗传学研究提供参考。

关键词: 高血压, 遗传易感性, 进化, 适应

Abstract:

Genetic studies, including familial linkage analysis, candidate gene approach and genome-wide association study, to some extent, have failed in detecting confirmative susceptibility genes/loci for essential hypertension (EH) in the general population. Previous genetic studies have suggested that differential susceptibility to many metabolic diseases is due to different environmental adaptation patterns during the out-of-Africa expansion, which provides a new strategy for the genetic study of EH. In this review, we introduce the principle and the latest progress of evolutionary study of susceptibility genes for EH. Furthermore, our recent evolutionary screening for EH susceptible genes/loci in Chinese Han population is also summarized. This review is expected to provide useful information for future genetic studies of EH and many other diseases.

Key words: essential hypertension, genetic susceptibility, evolution, adaptation