羊重要性状全基因组关联分析研究进展

doi:10.16288/j.yczz.17-021

遗传 ›› 2017, Vol. 39 ›› Issue (6): 491-500.doi: 10.16288/j.yczz.17-021

羊重要性状全基因组关联分析研究进展

张统雨(),朱才业,杜立新(),赵福平()

中国农业科学院北京畜牧兽医研究所,北京 100193

收稿日期:2017-01-16 修回日期:2017-02-16 出版日期:2017-06-20 发布日期:2017-03-20
作者简介:张统雨,在读硕士研究生,专业方向：羊遗传育种。E-mail: 877319693@qq.com|杜立新，博士，教授，研究方向：羊遗传育种。E-mail: lxdu@263.net|赵福平，博士，副研究员，研究方向：动物分子数量遗传。E-mail: zhaofuping@caas.cn
基金资助:
国家自然科学基金项目(31572357);国家科技支撑项目(2015BAD03B0503);中国农业科学院牧医所特设项目(ASTIP-IAS-TS-6)

Advances in genome-wide association studies for important traits in sheep and goats

Tongyu Zhang(),Caiye Zhu,Lixin Du(),Fuping Zhao()

Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received:2017-01-16 Revised:2017-02-16 Online:2017-06-20 Published:2017-03-20
Supported by:
the National Natural Science Foundation of China(31572357);National Program for Science and Technology Development(2015BAD03B0503);Agricultural Science and Technology Innovation Program(ASTIP-IAS-TS-6)

摘要/Abstract

摘要：

全基因组关联分析(genome-wide association study, GWAS)是一种复杂性状功能基因鉴定的分析策略,已成为挖掘畜禽重要经济性状候选基因的重要手段。随着绵羊和山羊基因组完成和公布,以及不同密度的SNP (single nucleotide polymorphism)芯片的推出并进行商业化推广,不仅大大丰富了羊标记辅助选择可利用的分子标记,而且还为开展重要性状的分子机理的探索提供了重要技术支撑。本文主要针对羊角、羊毛、羊奶、生长发育、肉质、繁殖和疾病等重要性状的GWAS研究所用的群体、主要研究方法和研究结果进行了综述,并对GWAS方法研究现状进行了归纳,以期为进一步利用GWAS进行羊的各种性状的遗传基础研究提供参考。

关键词: 全基因组关联分析, 基因组, 单核苷酸多态性, 复杂性状, 羊

Abstract:

Genome-wide association study (GWAS), an effective strategy to identify genetic variants associated with complex traits, has been used to study candidate genes of economical traits in animals. With the recent completion of sheep and goat genomes, single nucleotide polymorphism (SNP) chips of different densities are developed and commercialized. All these advances have enlarged the collection of molecular markers and also shed new light on the genetics of traits of interest in sheep and goats. In this review, we focus on the adoption of GWAS for important traits in sheep and goats, such as horn types, wool, dairy, growth and meat, reproduction and disease types, etc., and summarize the populations, major statistical methods and results of the GWAS analysis. Moreover, we also discuss the current state of GWAS, aiming to provide a reference for further studies on the genetic background of the important traits of sheep and goats by GWAS.

Key words: GWAS, genome, SNP, complex trait, sheep and goats

张统雨,朱才业,杜立新,赵福平. 羊重要性状全基因组关联分析研究进展[J]. 遗传, 2017, 39(6): 491-500.

Tongyu Zhang,Caiye Zhu,Lixin Du,Fuping Zhao. Advances in genome-wide association studies for important traits in sheep and goats[J]. Hereditas(Beijing), 2017, 39(6): 491-500.

参考文献

[1]	Quan C, Zhang XJ. Research strategies for the next step of genome-wide association study. Hereditas(Beijing), 2011, 33(2): 100-108.
[1]	权晟, 张学军. 全基因组关联研究的深度分析策略. 遗传, 2011, 33(2): 100-108.
[2]	Hirschhorn JN, Daly MJ. Genome-wide association studies for common diseases and complex traits. Nat Rev Genet, 2005, 6(2): 95-108.
[3]	Wang WY, Barratt BJ, Clayton DG, Todd JA. Genome- wide association studies: theoretical and practical concerns. Nat Rev Genet, 2005, 6(2): 109-118.
[4]	Wang JY, Wang HX, Chi RB, Guo JF, Wu Y. Progresses in research of genome-wide association studies in livestock and poultry. Scientia Agricultura Sinica, 2012, 46(4): 819-829.
[4]	王继英, 王海霞, 迟瑞宾, 郭建凤, 武英. 全基因组关联分析在畜禽中的研究进展. 中国农业科学, 2012, 46(4): 819-829.
[5]	China national comission of animal genetics resources. Animal genetics resource in China——Sheep and Goats. Beijing: China Agricultural Press, 2011.
[5]	国家畜禽遗传资源委员会组编. 中国畜禽遗传资源志—羊志. 北京: 中国农业出版社, 2011.
[6]	Dong Y, Xie M, Jiang Y, Xiao N, Du X, Zhang W, Tosser-Klopp G, Wang J, Yang S, Liang J, Chen W, Chen J, Zeng P, Hou Y, Bian C, Pan S, Li Y, Liu X, Wang W, Servin B, Sayre B, Zhu B, Sweeney D, Moore R, Nie W, Shen Y, Zhao R, Zhang G, Li J, Faraut T, Womack J, Zhang Y, Kijas J, Cockett N, Xu X, Zhao S, Wang J, Wang W. Sequencing and automated whole-genome optical mapping of the genome of a domestic goat (Capra hircus). Nat Biotechnol, 2013, 31(2): 135-141.
[7]	Jiang Y, Xie M, Chen W, Talbot R, Maddox JF, Faraut T, Wu C, Muzny DM, Li Y, Zhang W, Stanton J-A, Brauning R, Barris WC, Hourlier T, Aken BL, Searle SMJ, Adelson DL, Bian C, Cam GR, Chen Y, Cheng S, DeSilva U, Dixen K, Dong Y, Fan G, Franklin IR, Fu S, Fuentes-Utrilla P, Guan R, Highland MA, Holder ME, Huang G, Ingham AB, Jhangiani SN, Kalra D, Kovar CL, Lee SL, Liu W, Liu X, Lu C, Lv T, Mathew T, McWilliam S, Menzies M, Pan S, Robelin D, Servin B, Townley D, Wang W, Wei B, White SN, Yang X, Ye C, Yue Y, Zeng P, Zhou Q, Hansen JB, Kristiansen K, Gibbs RA, Flicek P, Warkup CC, Jones HE, Oddy VH, Nicholas FW, McEwan JC, Kijas JW, Wang J, Worley KC, Archibald AL, Cockett N, Xu X, Wang W, Dalrymple BP. The sheep genome illuminates biology of the rumen and lipid metabolism. Science, 2014, 344(6188): 1168-1173.
[8]	Kijas JW, Townley D, Dalrymple BP, Heaton MP, Maddox JF, McGrath A, Wilson P, Ingersoll RG, McCulloch R, McWilliam S, Tang D, McEwan J, Cockett N, Oddy VH, Nicholas FW, Raadsma H for the International Sheep Genomics Consortium. A genome wide survey of SNP variation reveals the genetic structure of sheep breeds. PLoS One, 2009, 4(3): e4668.
[9]	Tosser-klopp G, Bardou P, Bouchez O, Cabau C, Crooijmans R, Dong Y, Donnadieutonon C, Eggen A, Heuven HC, Jamli S, Jiken A, Klopp C, Lawley C, McEwan J, Martin P, Moreno C, Mulsant P, Nabihoudine I, Pa

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

羊重要性状全基因组关联分析研究进展

Advances in genome-wide association studies for important traits in sheep and goats

RichHTML

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics