遗传 ›› 2012, Vol. 34 ›› Issue (9): 1097-1107.doi: 10.3724/SP.J.1005.2012.01097
胡雨, 姚纪花
收稿日期:2012-02-25
修回日期:2012-03-28
出版日期:2012-09-20
发布日期:2012-09-25
通讯作者:
姚纪花
E-mail:yaojh@fudan.edu.cn
基金资助:国家重点基础研究发展计划(973计划)项目(编号：2011CB943804)资助
HU Yu, YAO Ji-Hua
Received:2012-02-25
Revised:2012-03-28
Online:2012-09-20
Published:2012-09-25
摘要： 哺乳动物多能性因子, 主要包括Pou5f1/Oct4、Sox2、Klf4、Nanog等转录因子, 不仅能够维持胚胎干细胞的未分化状态, 同时也参与使分化细胞重编程回多能性状态的过程。目前对脊椎动物多能性因子在体(in vivo)功能研究报道极少。斑马鱼是研究脊椎动物早期发育分化的理想模型, 它能够为多能性相关因子的功能研究提供在体环境, 因而可以更准确地了解多能性因子的作用信息。近年来, 已在斑马鱼中发现了多种哺乳动物多能性因子的同源基因, 如oct4、nanog等。文章主要介绍了斑马鱼中多能性因子的相关研究进展, 并与其它动物中的研究作一比较。
胡雨，姚纪花. 斑马鱼多能性因子的研究进展[J]. 遗传, 2012, 34(9): 1097-1107.
HU Yu, YAO Ji-Hua. Progress on pluripotency factors in zebrafish[J]. HEREDITAS, 2012, 34(9): 1097-1107.
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