多聚唾液酸(PSA)及其修饰的神经粘附分子(PSA-NCAM)对肿瘤及细胞信号通路的影响

doi:10.3724/SP.J.1005.2014.0739

遗传 ›› 2014, Vol. 36 ›› Issue (8): 739-746.doi: 10.3724/SP.J.1005.2014.0739

• 综述 • 下一篇

多聚唾液酸(PSA)及其修饰的神经粘附分子(PSA-NCAM)对肿瘤及细胞信号通路的影响

王欣^{1, 2}, 关锋^{1, 2}

1. 江南大学,糖化学与生物技术教育部重点实验室,无锡214122;
2. 江南大学生物工程学院,无锡 214122

收稿日期:2014-02-17 出版日期:2014-08-20 发布日期:2013-07-19
通讯作者: 关锋,博士,教授,研究方向：糖生物学。E-mail:fengguan@jiangnan.edu.cn
作者简介:王欣,博士研究生,专业方向：糖生物学。Tel: 0510-85918126;E-mail: emmaxin1@163.com
基金资助:
国家自然科学基金项目(编号：81201572)资助

The impact of polysialic acid (PSA) and polysialylated neural cell adhesion molecule (PSA-NCAM) on tumor and cell signaling pathways

Xin Wang^{1, 2}, Feng Guan^{1, 2}

1. Key Laboratory of Carbohydrate Chemistry & Biotechnology of Ministry of Education, Jiangnan University, Wuxi 214122, China;
2. School of Biotechnology, Jiangnan University, Wuxi 214122, China

Received:2014-02-17 Online:2014-08-20 Published:2013-07-19

摘要/Abstract

摘要： 神经粘附分子(Neural cell adhesion molecule, NCAM)是免疫球蛋白家族中的一员,在细胞粘附和细胞通信,尤其是神经系统的生长和塑型中起重要作用。而多聚唾液酸(Polysialic acid, PSA)则是控制NCAM粘附能力形成与神经系统分化的重要因素。研究发现,多种肿瘤细胞中存在PSA以及多聚唾液酸化的神经粘附分子(PSA-NCAM)再表达的现象,预示PSA及PSA-NCAM与多种肿瘤细胞的粘附性、迁移性和侵袭性等特性密切相关,影响肿瘤细胞的生长与转移,并通过介导多种细胞信号通路影响癌症的发生与发展。文章综述了NCAM以及PSA对癌症的发生与发展、预后的作用及其功能对细胞下游信号传导的影响。

关键词: 多聚唾液酸, NCAM, 信号通路, 肿瘤

Abstract: The neural cell adhesion molecule (NCAM), the member of the immunoglobulin superfamily, plays an important role in regulating cell adhesion and cell communication, particularly in nervous system wiring and plasticity. Polysialic acid, which is attached to NCAM on cell surface, is a prominent regulator of neural cell migration and differentiation during nervous system development. It has been demonstrated that PSA and PSA-NCAM were re-expressed in some malignant tumors. It was indicated that PSA and PSA-NCAM were tightly associated with cell adhesion, migration and invasion, and mediated tumor development and progression through certain cell signaling pathways. Here, we summarize the functional role of PSA, PSA-NCAM and related cell signaling pathways in tumor development, progression and prognostic.

Key words: polysialic acid, NCAM, signaling pathway, tumor

王欣, 关锋. 多聚唾液酸(PSA)及其修饰的神经粘附分子(PSA-NCAM)对肿瘤及细胞信号通路的影响[J]. 遗传, 2014, 36(8): 739-746.

Xin Wang, Feng Guan. The impact of polysialic acid (PSA) and polysialylated neural cell adhesion molecule (PSA-NCAM) on tumor and cell signaling pathways[J]. HEREDITAS(Beijing), 2014, 36(8): 739-746.

参考文献

[1] E, Vutskits L, Kiss JZ. The role of PSA-NCAM in adult neurogenesis . Adv Exp Med Biol , 2010, 663: 127- 136.
[2] L, Bose CM, Plattner F, Landmesser LT. Distinct roles of different neural cell adhesion molecule (NCAM) isoforms in synaptic maturation revealed by analysis of NCAM 180 kDa isoform-deficient mice . J Neurosci , 2004, 24(8): 1852-1864.
[3] S, Geyer H, Wuhrer M, Geyer R, Frank G, Ger-ardy-Schahn R, Zahringer U, Schachner M. Characteri-zation of N-glycans from mouse brain neural cell adhesion molecule . Glycobiology , 2001, 11(5): 373-384.
[4] JL, Rutishauser U. Roles, regulation, and mechan-ism of polysialic acid function during neural development . Biochimie , 2001, 83(7): 635-643.
[5] D, TroyII FA. Degree of polymerization (DP) of polysialic acid (polySia) on neural cell adhesion mole-cules (N-CAMS): development and application of a new strategy to accurately determine the DP of polySia chains on N-CAMS . J Biol Chem , 2005, 280(46): 38305-38316.
[6] F, Otake Y, Nakagawa T, Kawano Y, Miyahara R, Li M, Yanagihara K, Nakayama J, Fujimoto I, Ikenaka K, Wada H. Expression of polysialic acid and STX, a human polysialyltransferase, is correlated with tumor progression in non-small cell lung cancer . Cancer Res , 2000, 60(11): 3072-3080.
[7] C, Kitajima K. Disialic, oligosialic and polysialic acids: distribution, functions and related disease . J Biochem , 2013, 154(2): 115-136.
[8] S, Medrano JF. Primer on genes encoding enzymes in sialic acid metabolism in mammals . Biochimie , 2011, 93(10): 1641-1646.
[9] H, Li Y, Sun XL. Recent advances in sialic acid- focused glycomics . J Proteomics , 2012, 75(11): 3098-3112.
[10] RA, Errington RJ, Shnyder SD, Smith PJ, Patt-erson LH. Polysialyltransferase: a new target in metastatic cancer . Curr Cancer Drug Targets , 2012, 12(8): 925-939.
[11] S, Iwasaki M. Isolation of a novel glycoprotein from the eggs of rainbow trout: occurrence of disialosyl groups on all carbohydrate chains . Biochem Biophys Res Commun , 1978, 83(3): 1018-1023.
[12] J. Occurrence of unique polysialosyl carbohydrate units in glycoproteins of developing brain . J Biol Chem , 1982, 257(20): 11966-11970.
[13] U, Sato C, Matsuda T, Kitajima K. Polysialic acid in human milk - CD36 is a new member of mammalian poly-sialic acid-containing glycoprotein . J Biol Chem , 2003, 278(16): 13875-13880.
[14] S, Arany Z, Gerardy-Schahn R, Mann D, Stamatos NM. Polysialylated neuropilin-2 is expressed on the sur-face of human dendritic cells and modulates dendritic cell-T lymphocyte interactions . J Biol Chem , 2007, 282(42): 30346-30356.
[15] S, Hane M, Kitajima K, Sato C. Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid . J Biol Chem , 2012, 287(6): 3710-3722.
[16] M, Petit D, Forestier L, Karayan-Tapon L, Maftah A, Jauberteau MO, Battu S, Gallet FP, Lalloue F. Gly-cosylation-related gene expression is linked to differen-tiation status in glioblastomas undifferentiated cells . Cancer Lett , 2011, 312(1): 24-32.
[17] L, Yuanshu W, Yanying X, Zhongfa X, Jian Y, Feng-ling W, Xianjun Q, Kokudo N, Wei T, Weixia Z, Shuxiang C. Altered mRNA expressions of sialyltransferases in human gastric cancer tissues . Med Oncol , 2012, 29(1): 84-90.
[18] MC, Langley K, Rotsch M, Havemann K, Gratzl M. NCAM: a surface marker for human small cell lung cancer cells . FEBS Lett , 1990, 267(2): 295-300.
[19] MC, Coulibaly B, Chinot O, Loundou A, Met-ellus P, Rougon G, Figarella-Branger D. Polysialic acid neural cell adhesion molecule (PSA-NCAM) is an adverse prognosis factor in glioblastoma, and regulates olig2 exp-ression in glioma cell lines . BMC Cancer , 2010, 10: 91.
[20] F, Umemura S, Yasuda M, Osamura RY. Neuroen-docrine marker expression in thyroid epithelial tumors . Endocr Pathol , 2001, 12(3): 291-300.
[21] K, Oue N, Noguchi T, Sakamoto N, Matsusaki K, Yasui W. Immunostaining of gastric cancer with neur-oendocrin

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

多聚唾液酸(PSA)及其修饰的神经粘附分子(PSA-NCAM)对肿瘤及细胞信号通路的影响

The impact of polysialic acid (PSA) and polysialylated neural cell adhesion molecule (PSA-NCAM) on tumor and cell signaling pathways

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	孙清玙, 周阳, 杜丽娟, 张梦珂, 王家乐, 任媛媛, 刘芳. 巨噬细胞相关基因与非小细胞肺癌预后和肿瘤微环境的分析[J]. 遗传, 2023, 45(8): 684-699.
[2]	严程浩, 白韦钰, 张智猛, 沈俊岭, 王友军, 孙建伟. STIM1在肿瘤发生及转移中的研究进展[J]. 遗传, 2023, 45(5): 395-408.
[3]	马春辉, 胡海旭, 张丽娟, 刘毅, 刘天懿. 用于循环肿瘤细胞定量分析的CK19数字PCR检测方法的建立及性能验证[J]. 遗传, 2023, 45(3): 250-260.
[4]	常栋, 刘享享, 刘睿, 孙建伟. FSCN1在乳腺癌发生发展中的作用及其调控机制[J]. 遗传, 2023, 45(2): 115-127.
[5]	郝庆刚, 孙凤桂, 严程浩, 孙建伟. MT1-MMP在肿瘤转移中的研究进展[J]. 遗传, 2022, 44(9): 745-755.
[6]	孙凤宇, 许强华. 血液发生相关microRNAs研究进展[J]. 遗传, 2022, 44(9): 756-771.
[7]	赵岩, 王晨鑫, 杨天明, 李春爽, 张丽宏, 杜冬妮, 王若曦, 王静, 魏民, 巴雪青. DNA氧化损伤8-羟鸟嘌呤与肿瘤的发生发展[J]. 遗传, 2022, 44(6): 466-477.
[8]	唐湘薇, 楚丹, 颜赛娜, 尹艳飞, 卞桥, 翁波, 陈斌, 冉茂良. miR-191靶向BDNF基因通过激活PI3K/AKT信号通路促进猪未成熟支持细胞增殖[J]. 遗传, 2021, 43(7): 680-693.
[9]	寇艳妮, 岑山, 李晓宇. LINE-1在肿瘤早期诊断和治疗中的研究与应用[J]. 遗传, 2021, 43(6): 571-579.
[10]	张春霞, 刘峰. 造血干细胞发育过程中的信号通路调控[J]. 遗传, 2021, 43(4): 295-307.
[11]	王卓, 申笑涵, 施奇惠. 单细胞基因组测序技术新进展及其在生物医学中的应用[J]. 遗传, 2021, 43(2): 108-117.
[12]	刘倩, 李春燕. 增强子的鉴定及其在肿瘤研究中的应用[J]. 遗传, 2020, 42(9): 817-831.
[13]	赵利楠, 王娜, 杨国良, 苏现斌, 韩泽广. 基于单细胞靶向测序探究基因碱基突变的方法[J]. 遗传, 2020, 42(7): 703-712.
[14]	陈淑敏, 马铃, 岑山. Schlafen家族蛋白在肿瘤和病毒感染中的研究进展[J]. 遗传, 2020, 42(5): 444-451.
[15]	张强, 顾明亮. 单细胞测序技术及其在乳腺癌研究中的应用[J]. 遗传, 2020, 42(3): 250-268.