染色质构象与基因功能

doi:10.16288/j.yczz.19-257

遗传 ›› 2020, Vol. 42 ›› Issue (1): 1-17.doi: 10.16288/j.yczz.19-257

• 三维基因组专栏 • 下一篇

染色质构象与基因功能

黄其通, 李清, 张玉波()

中国农业科学院农业基因组研究所,“岭南现代农业”广东省实验室,深圳 518120

收稿日期:2019-08-29 修回日期:2019-10-29 出版日期:2020-01-20 发布日期:2019-11-19
通讯作者: 张玉波 E-mail:ribon_001@163.com
作者简介:黄其通,博士研究生,研究方向：动物三维基因组学。E-mail:miraclelive@qq.com|李清,硕士,研究方向：动物三维基因组学。E-mail: liqing9102@163.com; 黄其通和李清并列第一作者。
基金资助:
中国农业科学院科技创新工程、千人计划“青年项目”、中央级公益性科研院所基本科研业务费专项编号(Y2019PT18-02);国家自然科学基金面上项目编号(31970592);国家重点研发计划专项2018年度项目资助编号：(2018YFA0903201)

Linking chromatin conformation to gene function

Qitong Huang, Qing Li, Yubo Zhang()

Lingnan Guangdong Laboratory of Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China

Received:2019-08-29 Revised:2019-10-29 Online:2020-01-20 Published:2019-11-19
Contact: Zhang Yubo E-mail:ribon_001@163.com
Supported by:
Supported by the Agricultural Science and Technology Innovation Program, the Thousand Talents Plan for Young Professionals, the Fundamental Research Funds for Central Non-profit Scientific Institution No(Y2019PT18-02);the National Natural Science Foundation of China No(31970592);the National Key R&D Program of China No(2018YFA0903201)

摘要/Abstract

摘要：

在真核细胞中,DNA序列以染色质为载体,高度凝缩并存储于细胞核内,其复制、修复和转录表达等过程受到染色质构象的精准调控。越来越多的研究表明,特定的染色质构象可选择性激活或沉默基因,从而控制细胞自我维持或定向分化,决定细胞的组织特异性和细胞命运。因此,对染色质构象的深入研究已成为准确解析基因功能的一个关键切入点,也是当前基因组学研究所面临的一个巨大挑战。本文对染色质构象的研究历史、结构特征、动态调控机制进行了综述,并重点论述了不同维度构象特征对基因转录调控的影响,对该领域的研究难点进行了讨论,展望了其未来的发展方向,期望通过有效梳理染色质构象与基因调控之间的脉络关系,为未来该领域的研究提供参考。

关键词: 染色质构象, 基因功能, 动态调控

Abstract:

DNA is highly compressed and packaged as chromatin within the nucleus in eukaryotes. DNA replication, DNA repair and transcription, and other biological processes are precisely regulated or determined by chromatin conformation. Activation or repression of different genes/transcription factors are tightly correlated to their chromatin conformation which contributes to cell self-maintenance, differentiation, specificity and identity. Therefore, the study of bridging chromatin conformation to gene function has became crucial for decoding genetic information and precision biology which is also a great challenge for current genomics research. Here, we review the multiple aspects of chromatin conformation, including its history, characteristics, dynamics and the impact on different dimension-chromatin architecture to gene function. Additionally, we discuss the limitation and challenges of current status of linking chromatin conformation to gene function study. We believe this is informative and foundational in combing the context between chromatin conformation and gene function as reference.

Key words: chromatin conformation, gene function, dynamic regulation

黄其通, 李清, 张玉波. 染色质构象与基因功能[J]. 遗传, 2020, 42(1): 1-17.

Qitong Huang, Qing Li, Yubo Zhang. Linking chromatin conformation to gene function[J]. Hereditas(Beijing), 2020, 42(1): 1-17.

图/表 4

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染色质构象与基因功能

Linking chromatin conformation to gene function

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