合成生物学与微生物遗传物质的重构

doi:10.3724/SP.J.1005.2011.01102

遗传 ›› 2011, Vol. 33 ›› Issue (10): 1102-1112.doi: 10.3724/SP.J.1005.2011.01102

合成生物学与微生物遗传物质的重构

梁泉峰^1,2, 王倩², 祁庆生^1,2

1 山东大学微生物国家技术重点实验室, 济南250100 2 山东大学国家糖工程技术研究中心, 济南250100

收稿日期:2011-04-24 修回日期:2011-06-30 出版日期:2011-10-20 发布日期:2011-10-25
通讯作者: 祁庆生 E-mail:qiqingsheng@sdu.edu.cn
基金资助:
国家自然科学基金项目(编号：30870022)和国家重点基础研究发展规划(973计划)项目(编号：2011CB707405)资助

Synthetic biology and rearrangements of microbial genetic material

LIANG Quan-Feng^1,2, WANG Qian², QI Qing-Sheng^1,2

1. State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China 2. National Glycoengineering Research Center, Shandong University, Jinan 250100, China

Received:2011-04-24 Revised:2011-06-30 Online:2011-10-20 Published:2011-10-25

摘要/Abstract

摘要： 作为一门新兴学科的合成生物学已经展现出巨大的科学价值和应用前景。近年来已经发表了多篇综述文章, 从不同角度对合成生物学进行了总结和论述。文章首次对合成生物学和微生物遗传学之间的关系进行了阐述, 同时介绍了合成生物学在微生物遗传物质的重构方面最近的研究进展, 包括微生物遗传物质的合成、设计和精简, 遗传元件的标准化和遗传线路的模块化。也探讨了合成生物学与微生物遗传工程的关系。

关键词: 合成生物学, 遗传学, 微生物, 遗传物质, 微生物遗传工程

Abstract: As an emerging discipline, synthetic biology has shown great scientific values and application prospects. Although there have been many reviews of various aspects on synthetic biology over the last years, this article, for the first time, attempted to discuss the relationship and difference between microbial genetics and synthetic biology. We summarized the recent development of synthetic biology in rearranging microbial genetic materials, including synthesis, design and reduction of genetic materials, standardization of genetic parts and modularization of genetic circuits. The relationship between synthetic biology and microbial genetic engineering was also discussed in the paper.

Key words: synthetic biology, genetics, microorganism, genetic material, microbial genetic engineering

梁泉峰，王倩，祁庆生. 合成生物学与微生物遗传物质的重构[J]. 遗传, 2011, 33(10): 1102-1112.

LIANG Quan-Feng, WANG Qian, QI Qiang-Sheng. Synthetic biology and rearrangements of microbial genetic material[J]. HEREDITAS, 2011, 33(10): 1102-1112.

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合成生物学与微生物遗传物质的重构

Synthetic biology and rearrangements of microbial genetic material

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