表观遗传学与肿瘤干细胞

doi:10.3724/SP.J.1005.2013.01049

遗传 ›› 2013, Vol. 35 ›› Issue (9): 1049-1057.doi: 10.3724/SP.J.1005.2013.01049

• 综述 • 下一篇

表观遗传学与肿瘤干细胞

许力凡, 张记, 田志强, 吴玉章

第三军医大学免疫教研室, 重庆 400038

收稿日期:2013-03-13 修回日期:2013-05-12 出版日期:2013-09-20 发布日期:2013-09-25
通讯作者: 吴玉章 E-mail:Wuyuzhang@yahoo.com
基金资助:
长江学者和创新团队发展计划项目(编号：IRT1052)资助

Epigenetics in cancer stem cells

XU Li-Fan, ZHANG Ji, TIAN Zhi-Qiang, WU Yu-Zhang

Department of Immunology, The Third Military Medical University, Chongqing 400038, China

Received:2013-03-13 Revised:2013-05-12 Online:2013-09-20 Published:2013-09-25

摘要/Abstract

摘要：

肿瘤干细胞模型是关于肿瘤形成及生物学特征的一种重要观点。该模型认为肿瘤发生的核心是一群类似于成体干细胞的肿瘤细胞, 具有自我增殖和分化潜能, 称为肿瘤干细胞(Cancer stem cells, CSCs)。目前在多种肿瘤中都发现了CSCs, 其不仅能导致肿瘤发生, 还是引起肿瘤转移、复发、抗药的关键原因。因此, 研究CSC的调控机制具有重要意义。近年来的研究发现, 除了基础的遗传学因素外, 表观遗传学在CSCs的调控中同样具有重要作用。目前主要的表观遗传学机制包括DNA甲基化、组蛋白修饰、染色质重塑及miRNA等, 能有效调节基因表达及细胞表型, 也是肿瘤研究的新热点。文章主要围绕近几年CSCs的特性研究及表观遗传学线索, 阐述表观遗传学机制调控CSCs的最新进展。

关键词: DNA甲基化, 肿瘤干细胞, 组蛋白修饰

Abstract:

According to the types of stem cells and considering tumor evolution, one of the most significant theories about stem cells is derived from cancer stem cells (CSCs), which, similar to normal adult stem cells, possess the capacity of self-renewal and potential of differentiation. Over the past few years, compelling evidence has emerged in support of the CSC model for many tumors. The CSCs are posited to be responsible not only for tumor initiation but also for tumor metastasis, relapse and therapyresistance. Thus, understanding the mechanisms that govern the generation and maintenance of this special population of cells is of great importance. Despite the current progress in basic genetic research, the latest work implies that epigenetic mechanisms, from DNA methylation, histone modifications and chromatin-remodeling to the wide discovered miRNAs, play critical roles in the regulation of CSC features. This review focuses on the key epigenetic mechanisms that regulate and define the unique CSC properties.

Key words: DNA methylation, histone modification, cancer stem cells (CSCs)

中图分类号:

R394

许力凡张记田志强吴玉章. 表观遗传学与肿瘤干细胞[J]. 遗传, 2013, 35(9): 1049-1057.

XU Li-Fan ZHANG Ji TIAN Zhi-Qiang WU Yu-Zhang. Epigenetics in cancer stem cells[J]. HEREDITAS, 2013, 35(9): 1049-1057.

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表观遗传学与肿瘤干细胞

Epigenetics in cancer stem cells

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