遗传 ›› 2013, Vol. 35 ›› Issue (10): 1143-1152.doi: 10.3724/SP.J.1005.2013.01143

• 综述 •    下一篇

2型糖尿病环境因素与DNA甲基化的研究进展

汤琳琳1, 刘琼1,2, 步世忠1,2, 徐雷艇1,2, 王钦文1,2, 麦一峰3, 段世伟1,2   

  1. 1. 宁波大学医学院, 浙江省病理生理学技术研究重点实验室, 宁波 315211;
    2. 宁波大学医学院, 糖尿病研究中心, 宁波 315211;
    3. 宁波大学医学院附属医院, 宁波 315000
  • 收稿日期:2013-04-25 修回日期:2013-07-04 出版日期:2013-10-20 发布日期:2013-10-25
  • 通讯作者: 段世伟, 博士, 研究员, 研究方向:遗传学。 E-mail:duanshiwei@nbu.edu.cn
  • 作者简介:汤琳琳, 硕士研究生, 专业方向:内科学。E-mail: tll318@163.com
  • 基金资助:

    国家自然科学基金项目(编号:31100919), 浙江省自然科学基金杰出青年项目(编号:LR13H020003), 宁波市科技局/农业与社会发展攻关项目(编号:2012C50032), 宁波市自然科学基金项目(编号:2007A610077, 200701A6304004), 宁波大学重点学科项目(编号:XKL11D2117)和宁波大学王宽诚幸福基金项目资助

The effect of environmental factors and DNA methylation on type 2 diabetes mellitus

TANG Lin-Lin1, LIU Qiong1,2, BU Shi-Zhong1,2, XU Lei-Ting1,2, WANG Qin-Wen1,2, MAI Yi-Feng3, DUAN Shi-Wei1,2   

  1. 1. Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China; 
    2. Diabetes Center, Ningbo University, Ningbo 315211, China; 
    3. The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo 315000, China
  • Received:2013-04-25 Revised:2013-07-04 Online:2013-10-20 Published:2013-10-25

摘要:

2 型糖尿病(Type 2 diabetes mellitus, T2DM)是由于遗传与环境因素共同作用而引起葡萄糖代谢紊乱的疾病。DNA甲基化修饰的研究发现环境因素可以通过影响DNA甲基化修饰, 显著地增加T2DM的患病风险。目前, T2DM环境相关基因的DNA甲基化修饰研究已在人及动物的不同组织中取得进展。此外, T2DM相关基因的甲基化研究主要集中在糖代谢、能量代谢、炎症等。文章系统地综述了目前T2DM致病环境因素与DNA甲基化研究进展。

关键词: 2型糖尿病(T2DM), 表观遗传学, DNA甲基化, 环境因素

Abstract:

Type 2 diabetes mellitus (T2DM) is a glucose metabolic disorder driven by both genetic and environmental factors. Recent DNA methylation studies have established that T2DM may be contributed by environmental factors through the regulation of DNA methylation. Human and animal model studies have made much progress on the interaction between DNA methylation of T2DM genes and environmental factors in multiple tissues. Current studies on DNA methylation of T2DM genes mainly focus on glucose and energy metabolism, inflammation, and so on. This review comprehensively introduces the DNA methylation studies for the genes involved in T2DM and its related environmental factors.

Key words: type 2 diabetes mellitus, epigenetics, DNA methylation, environmental factors