[1] Drong AW, Lindgren CM, McCarthy MI. The genetic and epigenetic basis of type 2 diabetes and obesity. Clin Pharmacol Ther, 2012, 92(6): 707-715.<\p>
[2] Murea M, Ma LJ, Freedman BI. Genetic and environmental factors associated with type 2 diabetes and diabetic vascular complications. Rev Diabet Stud, 2012, 9(1): 6-22.<\p>
[3] Scheen AJ, Junien C.[Epigenetics, interface between environment and genes: role in complex diseases]. Rev Med Liege, 2012, 67(5-6): 250-257.<\p>
[4] Yagi S, Hirosawa M, Shiota K. DNA methylation profile: a composer-, conductor-, and player-orchestrated Mammalian genome consisting of genes and transposable genetic elements. J Reprod Dev, 2012, 58(3): 265-273.<\p>
[5] Keating ST, El-Osta A. Epigenetic changes in diabetes. Clin Genet, 2013, 84(1): 1–10.<\p>
[6] Melmed S, Polonsky KS, Larsen PR, Kronenberg HM. Williams textbook of endocrinology. 12th ed. Philadelphia: Elsevier/Saunders, 2012: 1371–1435.<\p>
[7] http://www.who.int/mediacentre/factsheets/fs312/en/.<\p>
[8] Teljeur C, Smith SM, Paul G, Kelly A, O'Dowd T. Multimorbidity in a cohort of patients with type 2 diabetes. Eur J Gen Pract, 2013, 19(1): 17-22.<\p>
[9] Tarride JE, Hopkins R, Blackhouse G, Bowen JM, Bischof M, Von Keyserlingk C, O'Reilly D, Xie F, Goeree R. A review of methods used in long-term cost-effectiveness models of diabetes mellitus treatment. Pharmacoeconomics, 2010, 28(4): 255-277.<\p>
[10] Hale PJ, Lopez-Yunez AM, Chen JY. Genome-wide meta-analysis of genetic susceptible genes for Type 2 Diabetes. BMC Syst Biol, 2012, 6 (Suppl. 3): S16.<\p>
[11] Campión J, Milagro F, Martínez JA. Epigenetics and obesity. Prog Mol Biol Transl Sci, 2010, 94: 291-347.<\p>
[12] Alibegovic AC, Sonne MP, Hojbjerre L, Bork-Jensen J, Jacobsen S, Nilsson E, Faerch K, Hiscock N, Mortensen B, Friedrichsen M, Stallknecht B, Dela F, Vaag A. Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men. Am J Physiol Endocrinol Metab, 2010, 299(5): E752-E763.<\p>
[13] Alasaari JS, Lagus M, Ollila HM, Toivola A, Kivim?ki M, Vahtera J, Kronholm E, H?rm? M, Puttonen S, Paunio T. Environmental stress affects DNA methylation of a CpG rich promoter region of serotonin transporter gene in a nurse cohort. PLoS ONE, 2012, 7(9): e45813.<\p>
[14] Kosik KS, Rapp PR, Raz N, Small SA, Sweatt JD, Tsai LH. Mechanisms of age-related cognitive change and targets for intervention: epigenetics. J Gerontol A Biol Sci Med Sci, 2012, 67(7): 741-746.<\p>
[15] Nugent BM, McCarthy MM. Epigenetic underpinnings of developmental sex differences in the brain. Neuroendocrinology, 2011, 93(3): 150-158.<\p>
[16] Reddington JP, Pennings S, Meehan RR. Non-canonical functions of the DNA methylome in gene regulation. Biochem J, 2013, 451(1): 13-23.<\p>
[17] Holliday R. Epigenetics: a historical overview. Epigenetics, 2006, 1(2): 76-80.<\p>
[18] Kar S, Deb M, Sengupta D, Shilpi A, Parbin S, Torrisani J, Pradhan S, Patra SK. An insight into the various regulatory mechanisms modulating human DNA methyltransferase 1 stability and function. Epigenetics, 2012, 7(9): 994-1007.<\p>
[19] Chédin F. The DNMT3 family of mammalian de novo DNA methyltransferases. Prog Mol Biol Transl Sci, 2011, 101: 255-285.<\p>
[20] Shen LL, Kondo Y, Guo Y, Zhang JX, Zhang L, Ahmed S, Shu JM, Chen XL, Waterland RA, Issa JPJ. Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet, 2007, 3(10): 2023-2036.<\p>
[21] Wang LQ, Liang R, Chim CS. Methylation of tumor suppressor microRNAs: lessons from lymphoid malignancies. Expert Rev Mol Diagn, 2012, 12(7): 755-765.<\p>
[22] Liu |