端粒酶调控研究进展

doi:10.16288/j.yczz.15-356

遗传 ›› 2016, Vol. 38 ›› Issue (4): 289-299.doi: 10.16288/j.yczz.15-356

端粒酶调控研究进展

营孙阳, 熊加秀, 麦洪旭, 林佳佳, 姜丽娜, 程龙, 叶棋浓

军事医学科学院生物工程研究所,北京 100850

收稿日期:2015-08-10 修回日期:2015-12-14 出版日期:2016-04-20 发布日期:2016-04-20
通讯作者: 叶棋浓,博士,研究员,研究方向：肿瘤分子生物学。Tel: 010-66931830;E-mail: yeqn66@yahoo.com
程龙,博士,副研究员,研究方向：肿瘤分子生物学。Tel: 010-66931830;E-mail: flonic@163.com
作者简介:营孙阳,硕士研究生,专业方向：遗传学。Tel: 010-66931830;E-mail: 929661078@qq.com
基金资助:
国家自然科学基金项目(编号：81330053)和北京市科技新星计划项目(编号：Z131102000413034)资助[Supported by the National Natural Science Foundation of China (No; 81330053) and Beijing Novo Program (No; Z131102000413034)],

Advances on the regulation of telomerase

Sunyang Ying, Jiaxiu Xiong, Hongxu Mai, Jiajia Lin, Lina Jiang, Long Cheng, Qinong Ye

Beijing Institute of Biotechnology, Beijing 100850, China

Received:2015-08-10 Revised:2015-12-14 Online:2016-04-20 Published:2016-04-20

摘要/Abstract

摘要： 端粒酶主要包括催化组分端粒酶逆转录酶(Telomerase reverse transcriptase, TERT)和端粒酶RNA组分(Telomerase RNA component, TERC),二者与其他端粒酶复合体亚基共同组装成具有延伸端粒末端功能的全酶,在细胞衰老和肿瘤发生过程中发挥关键的作用。端粒酶调控的分子机制复杂,调控过程包括组装前各组分的转录调节、转录后调控、翻译后修饰以及亚细胞定位的调控,还包括组装过程中各组分的运输和装配的调控,以及组装后募集到端粒末端的调控。本文从以上几个方面对端粒酶的调控机制进行了综述,旨在为端粒酶相关领域的研究以及开发以端粒酶为靶点的药物奠定理论基础。

关键词: 端粒酶, 端粒, 调控

Abstract: Telomerase is composed of the catalytic subunit TERT (Telomerase reverse transcriptase),RNA subunit TERC (Telomerase RNA component) and other telomerase associated proteins. These two compartments with other telomerase subunits can assemble a holoenzyme, which maintain the length of telomeres. Telomerase plays important roles in cell senescence and tumor formation. The molecular mechanisms of the regulation of telomerase are very complicated. These processes comprise the regulation of transcription, post-transcription, post-translation and subcellular localization. Trafficking and assemble of TERT and TERC, as well as recruitment to telomeres, are also involved in this process. Here we review the regulation mechanism of telomerase from these aspects, and aim to laid a foundation for telomerase associated research and the drug targeting the telomerase.

Key words: telomerase, telomere, regulation

营孙阳, 熊加秀, 麦洪旭, 林佳佳, 姜丽娜, 程龙, 叶棋浓. 端粒酶调控研究进展[J]. 遗传, 2016, 38(4): 289-299.

Sunyang Ying, Jiaxiu Xiong, Hongxu Mai, Jiajia Lin, Lina Jiang, Long Cheng, Qinong Ye. Advances on the regulation of telomerase[J]. HEREDITAS(Beijing), 2016, 38(4): 289-299.

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