遗传 ›› 2019, Vol. 41 ›› Issue (5): 404-412.doi: 10.16288/j.yczz.19-042

• 综述 • 上一篇    下一篇

m 6A修饰及其对病毒复制过程调控研究进展

薛鹏1,蒋涛1,沈兴家1,2()   

  1. 1. 江苏科技大学生物技术学院,江苏省蚕桑生物学与生物技术重点实验室,镇江 212018
    2. 中国农业科学院蚕业研究所,农业部蚕桑遗传改良重点实验室,镇江 212018
  • 收稿日期:2019-02-20 修回日期:2019-04-08 出版日期:2019-05-20 发布日期:2019-04-16
  • 通讯作者: 沈兴家 E-mail:shenxjsri@163.com
  • 作者简介:薛鹏,硕士研究生,专业方向:基因表达调控。E-mail: xuepeng0603@163.com
  • 基金资助:
    国家自然科学基金项目(31672490);江苏省自然科学基金项目(BK20151322);江苏省高校自然科学研究重大项目(15KJA180001)

Advances in m 6A modification and its regulation of viral replication

Xue Peng1,Jiang Tao1,Shen Xingjia1,2()   

  1. 1. Jiangsu Key Laboratory of Sericutural Biology and Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212018, China
    2. Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture, Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang 212018, China
  • Received:2019-02-20 Revised:2019-04-08 Online:2019-05-20 Published:2019-04-16
  • Contact: Shen Xingjia E-mail:shenxjsri@163.com
  • Supported by:
    National Natural Science Foundation of China(31672490);Natural Science Foundation of Jiangsu Province(BK20151322);Major Project of Natural Science Foundation for Universities of Jiangsu Province(15KJA180001)

摘要:

N 6-甲基腺嘌呤(N 6-methyladenosine, m 6A)修饰是一种在真核生物中普遍存在的RNA修饰方式,在mRNA转运、稳定、翻译等过程中具有重要作用。m 6A修饰在病毒复制周期中扮演不同的角色,病毒的复制和宿主对病毒的免疫反应都受到m 6A甲基化的影响。本文总结了近年来关于m 6A修饰方面的分子作用机制及其对病毒复制以及宿主免疫反应的影响相关研究,以期为病毒生命周期中的表观遗传调控研究提供一定的参考。

关键词: N 6-甲基腺嘌呤, RNA修饰, 病毒, 复制, 免疫

Abstract:

N 6-methyladenosine (m 6A) is a prevalent modification of RNA in eukaryotes and plays an important role in the process of mRNA translocation, stabilization and translation. m 6A exerts different influences on the viral replication cycle, and both viral replication and host immune response to the virus are affected by m 6A. In this review, we summarize recent studies on the mechanism of m 6A modification and its effects on viral replication and host immune response, in order to provide a reference for epigenetic regulation in the viral life cycle.

Key words: N 6-methyladenosine, RNA modification, virus, replication, immunity