遗传 ›› 2022, Vol. 44 ›› Issue (9): 745-755.doi: 10.16288/j.yczz.22-213

• 综述 • 上一篇    下一篇

MT1-MMP在肿瘤转移中的研究进展

郝庆刚1(), 孙凤桂2, 严程浩1, 孙建伟1()   

  1. 1. 云南大学生命科学学院,生命科学研究中心,昆明 650504
    2. 山东省寿光市人民医院听力筛查室,寿光 262750
  • 收稿日期:2022-06-22 修回日期:2022-08-01 出版日期:2022-09-20 发布日期:2022-08-15
  • 通讯作者: 孙建伟 E-mail:haoqinggang@yeah.net;jwsun@ynu.edu.cn
  • 作者简介:郝庆刚,在读博士研究生,研究方向:细胞生物学。E-mail: haoqinggang@yeah.net
  • 基金资助:
    云南省应用基础研究基金(编号)(202101AV070002);云南省应用基础研究基金(编号)(2019FY003030);云南省科技计划重大专项编号(202102AA310055);云南大学第十三届研究生科研创新项目(编号)资助(2021Z088)

Progress on the role and mechanism of MT1-MMP in tumor metastasis

Qinggang Hao1(), Fenggui Sun2, Chenghao Yan1, Jianwei Sun1()   

  1. 1. Center for life Sciences, School of life Sciences, Yunnan University, Kunming 650504, China
    2. Department of Hearing Screening Room, Shouguang People's Hospital of Shandong Province, Shouguang 262750, China
  • Received:2022-06-22 Revised:2022-08-01 Online:2022-09-20 Published:2022-08-15
  • Contact: Sun Jianwei E-mail:haoqinggang@yeah.net;jwsun@ynu.edu.cn
  • Supported by:
    Supported by the Applied Basic Research Foundation of Yunnan Province Nos(202101AV070002);Supported by the Applied Basic Research Foundation of Yunnan Province Nos(2019FY003030);the Major Science and Technique Programs in Yunnan Province No(202102AA310055);the 13th Graduate Scientific Research Innovation Project of Yunnan University No(2021Z088)

摘要:

基质金属蛋白酶(matrix metallopeptidase, MMPs)家族是一类锌依赖性内肽酶,可降解大多数细胞外基质。MT1-MMP是MMPs家族的重要成员,定位在细胞膜上,并在多种肿瘤中高表达。MT1-MMP通过影响细胞外基质重塑、血管生成、脂质代谢、炎症反应等过程促进肿瘤转移。然而,其具体的调控作用机制仍未完全阐明。本文综述了目前MT1-MMP在各系统肿瘤中的最新研究进展,总结并探讨了其在肿瘤中的促转移调控机制,为其在肿瘤领域的深入研究和应用提供借鉴和参考。

关键词: MT1-MMP, 肿瘤, 转移, 转运, 回收

Abstract:

The matrix metallopeptidase family (matrix metallopeptidase, MMPs) is a class of zinc-dependent endopeptidases that can degrade most extracellular matrices. MT1-MMP (membrane type 1 metalloprotease) is an important metallopeptidase, which is located on plasma membrane and highly expressed in most tumors. MT1-MMP promotes cancer metastasis through affecting the extracellular matrix remodeling, angiogenesis, lipid metabolism, and inflammation. However, the mechanisms of MT1-MMP in different tumors have not been fully elucidated. In this review, we summarize the latest progress and the metastasis-promoting regulatory mechanisms of MT1-MMP in different tumors, which will provide references for its in-depth research and application in the field of cancer biology.

Key words: MT1-MMP, tumor, metastasis, trafficking, recycling