生殖细胞及早期胚胎基因组印记的表观调控

doi:10.16288/j.yczz.15-194

遗传 ›› 2016, Vol. 38 ›› Issue (2): 103-108.doi: 10.16288/j.yczz.15-194

生殖细胞及早期胚胎基因组印记的表观调控

朱屹然,张美玲,翟志超,赵云蛟,马馨

吉林农业大学动物科学技术学院,长春 130118

收稿日期:2015-05-06 修回日期:2015-07-24 出版日期:2016-02-20 发布日期:2015-11-04
通讯作者: 马馨,博士,副教授,研究方向：动物克隆与转基因动物。E-mail: maxin3202@163.com
作者简介:朱屹然,硕士研究生,专业方向：动物克隆与转基因动物。E-mail: zyr901027@163.com
基金资助:
国家自然科学基金青年基金项目(编号：31302047)资助[Supported by the National Natural Science Foundation of China (No; 31302047)]

Epigenetic regulation of genomic imprinting in germline cells and preimplantation embryos

Yiran Zhu, Meiling Zhang, Zhichao Zhai, Yunjiao Zhao, Xin Ma

College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China

Received:2015-05-06 Revised:2015-07-24 Online:2016-02-20 Published:2015-11-04

摘要/Abstract

摘要： 基因组印记是一种区别父母等位基因的表观遗传过程,可导致父源和母源基因特异性表达。印记是在配子发生过程中全基因组表观重编程时获得的,且在早期胚胎发育过程中得以维持。因此,在全基因组重编程过程中,对印记的识别和维持十分重要。本文概述了原始生殖细胞的印记清除、双亲原始生殖细胞的印记获得以及早期胚胎发育过程中印记维持的相关过程,并对在印记区域内保护印记基因免受全基因组DNA去甲基化的表观遗传因子的相关作用机制进行了讨论。

关键词: 基因组印记, DNA甲基化, 早期胚胎发育

Abstract: Genomic imprinting is an epigenetic process that distinguishes parental alleles and results in specific expression of paternal and maternal genes. Imprints are acquired in the process of gametogenesis when genome-wide epigenetic reprogramming occurs and are maintained during early embryonic development. Therefore, the recognition and maintenance of imprints are very important in genome-wide reprogramming. In this review, we summarize the progresses of imprints removal in primordial germ cells (PGCs), imprints acquisition in parental PGCs, and imprints maintenance during early embryonic development. We also discuss the functional mechanisms of epigenetic factors which protect imprinted genes from whole genome DNA methylation.

Key words: genomic imprinting, DNA methylation, preimplantation embryos

朱屹然,张美玲,翟志超,赵云蛟,马馨. 生殖细胞及早期胚胎基因组印记的表观调控[J]. 遗传, 2016, 38(2): 103-108.

Yiran Zhu, Meiling Zhang, Zhichao Zhai, Yunjiao Zhao, Xin Ma. Epigenetic regulation of genomic imprinting in germline cells and preimplantation embryos[J]. HEREDITAS(Beijing), 2016, 38(2): 103-108.

参考文献

[1] Ma X, Zhang S, Yang SB, Wang XC, Zhu YR, Li ZY, Luan WM.The roles of maternal-effect proteins in the maintenance of genomic imprints. Hereditas (Beijing) , 2014, 36(10): 959-964. 马馨, 张胜, 杨树宝, 王晓晨, 朱屹然, 李子义, 栾维民. 母源效应蛋白在基因组印记维持中的作用. 遗传, 2014, 36(10): 959-964.
[2] Kobayashi H, Sakurai T, Imai M, Takahashi N, Fukuda A, Yayoi O, Sato S, Nakabayashi K, Hata K, Sotomaru Y, Suzuki Y, Kono T. Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks. PLoS Genet , 2012, 8(1): e1002440.
[3] Smallwood SA, Tomizawa S, Krueger F, Ruf N, Carli N, Segonds-Pichon A, Sato S, Hata K, Andrews SR, Kelsey G. Dynamic CpG island methylation landscape in oocytes and preimplantation embryos. Nat Genet , 2011, 43(8): 811-814.
[4] Smith ZD, Chan MM, Mikkelsen TS, Gu HC, Gnirke A, Regev A, Meissner A. A unique regulatory phase of DNA methylation in the early mammalian embryo. Nature , 2012, 484(7394): 339-344.
[5] Tomizawa SI, Kobayashi H, Watanabe T, Andrews S, Hata K, Kelsey G, Sasaki H. Dynamic stage-specific changes in imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes. Development , 2011, 138(5): 811-820.
[6] Proudhon C, Duffié R, Ajjan S, Cowley M, Iranzo J, Carbajosa G, Saadeh H, Holland ML, Oakey RG, Rakyan VK, Schulz R, Bourc’his D. Protection against de novo methylation is instrumental in maintaining parent-of-origin methylation inherited from the gametes. Mol Cell , 2012, 47(6): 909-920.
[7] Kelsey G, Feil R. New insights into establishment and maintenance of DNA methylation imprints in mammals. Philos Trans R Soc Lond B Biol Sci , 2013, 368(1609): 20110336.
[8] Saitou M, Kagiwada S, Kurimoto K. Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells. Development , 2012, 139(1): 15-31.
[9] Guibert S, Forné T, Weber M. Global profiling of DNA methylation erasure in mouse primordial germ cells. Genome Res , 2012, 22(4): 633-641.
[10] Seisenberger S, Andrews S, Krueger F, Arand J, Walter J, Santos F, Popp C, Thienpont B, Dean W, Reik W. The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells. Mol Cell , 2012, 48(6): 849-862.
[11] Yamaguchi S, Hong K, Liu R, Inoue A, Shen L, Zhang K, Zhang Y. Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming. Cell Res , 2013, 23(3): 329-339.
[12] Kagiwada S, Kurimoto K, Hirota T, Yamaji M, Saitou M. Replication-coupled passive DNA demethylation for the erasure of genome imprints in mice. EMBO J , 2013, 32(3): 340-353.
[13] Piccolo FM, Bagci H, Brown KE, Landeira D, Soza-Ried J, Feytout A, Mooijman D, Hajkova P, Leitch HG, Tada T, Kriaucionis S, Dawlaty MM, Jaenisch R, Merkenschlager M, Fisher AG. Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion. Mol Cell , 2013, 49(6): 1023-1033.
[14] Vincent JJ, Huang Y, Chen PY, Feng SH, Calvopiña JH, Nee K, Lee SA, Le T, Yoon AJ, Faull K, Fan GP, Rao A, Jacobsen SE, Pellegrini M, Clark AT. Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells. Cell Stem Cell , 2013, 12(4): 470-478.
[15] Hackett JA, Sengupta R, Zylicz JJ, Murakami K, Lee C, Down TA, Surani MA. Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine. Science , 2013, 339(6118): 448-452.
[16] Kobayashi H, Sakurai T, Miura F, Imai M, Mochiduki K, Yanagisawa E, Sakashita A, Wakai T, Suzuki Y, Ito T, Matsui Y, Kono T. High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice. Genome Res , 2013, 23(4): 616-627.
[17] Lee DH, Singh P, Tsai SY, Oates N, Spalla A, Spalla C, Brown L, Rivas G, Larson G, Rauch TA, Pfeifer GP, Szabó PE. CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia. PLoS Genet , 2010, 6(11): e1001224.
[18] Hammoud SS, Nix DA, Zhang HY, Purwar J, Carrell DT, Cairns BR. Distinctive chromatin in human sperm packages genes for embryo development. Nature , 2009, 460(7254): 473-478.
[19] Brykczynska U, Hisano M, Erkek S, Ramos L, Oakeley EJ, Roloff TC, Beisel C, Schübeler D, Stadler MB, Peters AH. Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa. Nat Struct Mol Biol , 2010, 17(6): 679-687.
[20] Henckel A, Chebli K, Kota SK, Arnaud P, Feil R. Transcription and histone methylation changes correlate with imprint acquisition in male germ cells. EMBO J , 2012, 31(3): 606-615.
[21] Nakamura T, Liu YJ, Nakashima H, Umehara H, Inoue K, Matoba S, Tachibana M, Ogura A, Shinkai Y, Nakano T. PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos. Nature , 2012, 486(7403): 415-419.
[22] Watanabe T, Tomizawa SI, Mitsuya K, Totoki Y, Yamamoto Y, Kuramochi-Miyagawa S, Iida N, Hoki Y, Murphy PJ, Toyoda A, Gotoh K, Hiura H, Arima T, Fujiyama A, Sado T, Shibata T, Nakano T, Lin HF, Ichiyanagi K, Soloway PD, Sasaki H. Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science , 2011, 332(6031): 848-852.
[23] Denomme MM, White CR, Gillio-Meina C, Macdonald WA, Deroo BJ, Kidder GM, Mann MR. Compromised fertility disrupts Peg1 but not Snrpn and Peg3 imprinted methylation acquisition in mouse oocytes. Front Genet , 2012, 3: 219.
[24] Quenneville S, Verde G, Corsinotti A, Kapopoulou A, Jakobsson J, Offner S, Baglivo I, Pedone PV, Grimaldi G, Riccio A, Trono D. In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions. Mol Cell , 2011, 44(3): 361-372.
[25] Ciccone DN, Su H, Hevi S, Gay F, Lei H, Bajko J, Xu GL, Li E, Chen TP. KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature , 2009, 461(7262): 415-418.
[26] Gu TP, Guo F, Yang H, Wu HP, Xu GF, Liu W, Xie ZG, Shi LY, He XY, Jin SG, Iqbal K, Shi YG, Deng ZX, Szabó PE, Pfeifer GP, Li JS, Xu GL. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature , 2011, 477(7366): 606-610.
[27] Inoue A, Zhang Y. Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. Science , 2011, 334(6053): 194.
[28] Ito S, D’Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature , 2010, 466(7310): 1129-1133.
[29] Iqbal K, Jin SG, Pfeifer GP, Szabó PE. Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci USA , 2011, 108(9): 3642-3647.
[30] Szulwach KE, Li XK, Li YJ, Song CX, Wu H, Dai Q, Irier H, Upadhyay AK, Gearing M, Levey AI, Vasanthakumar A, Godley LA, Chang Q, Cheng XD, He C, Jin P. 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci , 2011, 14(12): 1607-1616.
[31] Mellén M, Ayata P, Dewell S, Kriaucionis S, Heintz N. MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell , 2012, 151(7): 1417-1430.
[32] Yildirim O, Li RW, Hung JH, Chen PB, Dong XJ, Ee LS, Weng ZP, Rando OJ, Fazzio TG. Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells. Cell , 2011, 147(7): 1498-1510.
[33] Williams K, Christensen J, Pedersen MT, Johansen JV, Cloos PAC, Rappsilber J, Helin K. TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature , 2011, 473(7347): 343-348.
[34] Messerschmidt DM, de Vries W, Ito M, Solter D, Ferguson-Smith A, Knowles BB. Trim28 is required for epigenetic stability during mouse oocyte to embryo transition. Science , 2012, 335(6075): 1499-1502.
[35] Zuo XP, Sheng JP, Lau HT, McDonald CM, Andrade M, Cullen DE, Bell FT, Iacovino M, Kyba M, Xu GL, Li XJ. Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain. J Biol Chem , 2012, 287(3): 2107-2118.

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生殖细胞及早期胚胎基因组印记的表观调控

Epigenetic regulation of genomic imprinting in germline cells and preimplantation embryos

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