遗传 ›› 2016, Vol. 38 ›› Issue (12): 1043-1055.doi: 10.16288/j.yczz.16-238
• 综述 • 下一篇
刘姝丽，张胜利，俞英
收稿日期:2016-07-04
修回日期:2016-11-13
出版日期:2016-12-20
发布日期:2016-11-17
通讯作者:
俞英，副教授，博士生导师，研究方向：动物分子抗病育种及表观遗传调控。E-mail: yuying@cau.edu.cn 张胜利，男，教授，博士生导师，研究方向：奶牛育种。E-mail: zhang62733697@163.com
作者简介:刘姝丽，博士研究生，专业方向：动物分子数量遗传学。E-mail: liushulihaha@163.com
基金资助:Shuli Liu, Shengli Zhang, Ying Yu
Received:2016-07-04
Revised:2016-11-13
Online:2016-12-20
Published:2016-11-17
Supported by:摘要： 同卵双胞胎来源于同一个受精卵，DNA序列基本一致，但在某些重要表型上如复杂疾病，并不完全一样。利用表型不一致的同卵双胞胎进行研究，能在遗传背景、母体效应、年龄性别效应等一致的基础上，深入研究分析复杂性状的表观调控机制。而DNA甲基化是最为稳定的一类表观遗传修饰。在人类中，利用同卵双胞胎对印记异常疾病、精神类疾病、自身免疫病及癌症等疾病的DNA甲基化调控研究已经揭示了多个致病基因，为研究疾病的表观调控以及表观遗传学药物的应用打下了基础。本文着重对同卵双胞胎DNA甲基化状态、DNA甲基化遗传力计算以及复杂性状DNA甲基化调控的研究应用及其进展展开综述，以期为复杂性状表观调控机制研究提供借鉴和参考。
刘姝丽，张胜利，俞英. 同卵双胞胎在复杂性状DNA甲基化调控机制研究中的应用[J]. 遗传, 2016, 38(12): 1043-1055.
Shuli Liu, Shengli Zhang, Ying Yu. Research progress of regulatory mechanism of DNA methylation in complex traits using monozygotic twins[J]. Hereditas(Beijing), 2016, 38(12): 1043-1055.
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