同卵双胞胎在复杂性状DNA甲基化调控机制研究中的应用

doi:10.16288/j.yczz.16-238

遗传 ›› 2016, Vol. 38 ›› Issue (12): 1043-1055.doi: 10.16288/j.yczz.16-238

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同卵双胞胎在复杂性状DNA甲基化调控机制研究中的应用

刘姝丽，张胜利，俞英

中国农业大学动物科技学院，北京 100193

收稿日期:2016-07-04 修回日期:2016-11-13 出版日期:2016-12-20 发布日期:2016-11-17
通讯作者: 俞英，副教授，博士生导师，研究方向：动物分子抗病育种及表观遗传调控。E-mail: yuying@cau.edu.cn 张胜利，男，教授，博士生导师，研究方向：奶牛育种。E-mail: zhang62733697@163.com
作者简介:刘姝丽，博士研究生，专业方向：动物分子数量遗传学。E-mail: liushulihaha@163.com
基金资助:
国家自然科学基金项目(编号：31272420)，国家奶业产业技术体系项目(编号：CARS-37-04B)和长江学者与创新团队发展计划项目(编号：IRT1191)资助

Research progress of regulatory mechanism of DNA methylation in complex traits using monozygotic twins

Shuli Liu, Shengli Zhang, Ying Yu

College of Animal Science and Technology, China Agricultural University, Beijing 100193, China

Received:2016-07-04 Revised:2016-11-13 Online:2016-12-20 Published:2016-11-17
Supported by:
Supported by the National Natural Science Foundation of China (No. 31272420), Modern Agro-industry Technology Research System (No. CARS-37-04B) and the Program for Changjiang Scholar and Innovation Research Team in University (No. IRT1191)

摘要/Abstract

摘要： 同卵双胞胎来源于同一个受精卵，DNA序列基本一致，但在某些重要表型上如复杂疾病，并不完全一样。利用表型不一致的同卵双胞胎进行研究，能在遗传背景、母体效应、年龄性别效应等一致的基础上，深入研究分析复杂性状的表观调控机制。而DNA甲基化是最为稳定的一类表观遗传修饰。在人类中，利用同卵双胞胎对印记异常疾病、精神类疾病、自身免疫病及癌症等疾病的DNA甲基化调控研究已经揭示了多个致病基因，为研究疾病的表观调控以及表观遗传学药物的应用打下了基础。本文着重对同卵双胞胎DNA甲基化状态、DNA甲基化遗传力计算以及复杂性状DNA甲基化调控的研究应用及其进展展开综述，以期为复杂性状表观调控机制研究提供借鉴和参考。

关键词: 同卵双胞胎, DNA甲基化, 复杂性状, DNA甲基化遗传力

Abstract: Coming from a single zygote, monozygotic (MZ) twins share nearly all of their genetic materials and are almost strikingly similar in appearance. Yet they are often discordant for important phenotypes including complex diseases. The study of discordant MZ twins allows us to understand the role of epigenetics in complex traits by controlling many potential confounders, such as genetic factors, maternal effects, age and sex. As we know, DNA methylation is the most stable epigenetic modification. In human, many causal genes, regulating disease status by DNA methylation modification in imprinting disorders, psychological disorders, autoimmune diseases and cancers, have been discovered, which provides a foundation for studying epigenetic regulation of diseases and application of epigenetic drugs. This article reviews the latest findings on DNA methylation status, estimates of DNA methylation heritability as well as studies of DNA methylation regulation in complex traits using MZ twins, in order to provide reference for research on epigenetic modification in complex traits.

Key words: monozygotic twins, DNA methylation, complex traits, heritability of DNA methylation

刘姝丽，张胜利，俞英. 同卵双胞胎在复杂性状DNA甲基化调控机制研究中的应用[J]. 遗传, 2016, 38(12): 1043-1055.

Shuli Liu, Shengli Zhang, Ying Yu. Research progress of regulatory mechanism of DNA methylation in complex traits using monozygotic twins[J]. Hereditas(Beijing), 2016, 38(12): 1043-1055.

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同卵双胞胎在复杂性状DNA甲基化调控机制研究中的应用

Research progress of regulatory mechanism of DNA methylation in complex traits using monozygotic twins

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