母源效应蛋白在基因组印记维持中的作用

doi:10.3724/SP.J.1005.2014.0959

遗传 ›› 2014, Vol. 36 ›› Issue (10): 959-964.doi: 10.3724/SP.J.1005.2014.0959

• 综述 • 下一篇

母源效应蛋白在基因组印记维持中的作用

马馨^1,2,张胜²,杨树宝¹,王晓晨¹,朱屹然¹,李子义²,栾维民¹

1. 吉林农业大学动物科技学院,动物生产及产品质量安全教育部重点实验室,长春 130118;
2. 吉林大学动物医学学院,长春 130062

收稿日期:2014-06-20 出版日期:2014-10-20 发布日期:2014-10-20
通讯作者: 栾维民,博士,教授,研究方向：免疫器官发生发育。E-mail: luanweimin@aliyun.com;李子义,博士,教授,研究方向：动物克隆与转基因动物。E-mail: ziyi@jlu.edu.cn E-mail:maxin3202@163.com
作者简介:马馨,博士,副教授,研究方向：动物克隆与转基因动物。E-mail: maxin3202@163.com
基金资助:
国家自然科学基金青年基金项目(编号：31302047)资助

The roles of maternal-effect proteins in the maintenance of genomic imprints

Xin Ma^{1, 2}, Sheng Zhang², Shubao Yang¹, Xiaochen Wang¹, Yiran Zhu¹, Ziyi Li², Weimin Luan¹

1. College of Animal Science and Technology, Key Laboratory of Animal Production and Production Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun 130118, China;
2. College of Veterinary Medicine, Jilin University, Changchun 130062, China

Received:2014-06-20 Online:2014-10-20 Published:2014-10-20

摘要/Abstract

摘要： 基因组印记是指生殖细胞发生过程中双亲基因组发生差异表观修饰,使带有亲代印记的等位基因出现父源或母源单等位基因表达。在配子发生和早期胚胎发育过程中,基因组印记甲基化经历一个去除、重建和维持的复杂过程。这个过程中的任何环节被干扰都将导致印记紊乱,造成胚胎发生、胎盘形成及出生后发育异常。近来研究表明,早期胚胎发育过程中一些母源效应蛋白在印记基因表观调控中起重要作用。为了更好地理解这些母源因子对印记基因建立及维持的作用与机制,文章综述了DPPA3、ZFP57、TRIM28和DNMT1等母源效应因子近年来的相关研究进展,并探讨了这些因子对基因组印记的表观调控机制。

关键词: 基因组印记, 母源调控基因, DNA甲基化, 植入前胚胎

Abstract: Genomic imprinting is a mechanism of differentially epigenetic modification that restricts monoallelic expression to either the maternally or paternally inherited copy of the gene during gametogenesis. Imprinted methylation undergoes a process of erasure, acquisition, and maintenance during gametogenesis and early embryogenesis. Disruptions in any of these steps may lead to imprinting disorders, resulting in the aberrant development of embryogenesis, placentation and postnatal growth. Recent studies have shown that maternal-effect proteins are important for the regulation of imprinted gene during the development of preimplantation embryos. In order to obtain a better understanding for the mechanism of maternal-effect proteins in the maintenance of genomic imprints, the recent study progress of maternal-effect proteins, such as DPPA3, ZFP57, TRIM28 and DNMT1, are summarized, and the regulation mechanism of these maternal-effect proteins for genomic imprints are discussed.

Key words: genomic imprinting, maternal-effect genes, DNA methylation, preimplantation embryos

马馨,张胜,杨树宝,王晓晨,朱屹然,李子义,栾维民. 母源效应蛋白在基因组印记维持中的作用[J]. 遗传, 2014, 36(10): 959-964.

Xin Ma, Sheng Zhang, Shubao Yang, Xiaochen Wang, Yiran Zhu, Ziyi Li, Weimin Luan. The roles of maternal-effect proteins in the maintenance of genomic imprints[J]. HEREDITAS(Beijing), 2014, 36(10): 959-964.

参考文献

[1] T, Obata Y, Wu Q, Niwa K, Ono Y, Yamamoto Y, Park ES, Seo JS, Ogawa H. Birth of parthenogenetic mice that can develop to adulthood. Nature , 2004, 428(6985): 860-864.
[2] NM, Donnelly CA, Anderson RM. The foot- and-mouth epidemic in Great Britain: pattern of spread and impact of interventions. Science , 2001, 292(5519): 1155-1160.
[3] CM, Blake A, Thomas S, Beechey CV, Hancock J, Cattanach BM, Peters J. World Wide Web Site- Mouse Imprinting Data and References. MRC Harwell, Oxfordshire, 2013, http://www.har.mrc.ac.uk/research/geno-mic_ imprinting/.
[4] L, Barlow DP. An ICE pattern crystallizes. Nat Genet , 2003, 35(1): 11-12.
[5] G, Feil R. New insights into establishment and maintenance of DNA methylation imprints in mammals. Philos Trans R Soc Lond B Biol Sci , 2013, 368(1609): 20110336.
[6] MM, Mann MRW. Genomic imprints as a model for the analysis of epigenetic stability during assisted reproductive technologies. Reproduction , 2012, 144(4): 393-409.
[7] A, Chebli K, Kota SK, Arnaud P, Feil R. Transcription and histone methylation changes correlate with imprint acquisition in male germ cells. EMBO J , 2012, 31(3): 606-615.
[8] HD, Santos F, Green K, Dean W, Reik W. Epigenetic reprogramming in mammals. Hum Mol Genet , 2005, 14(Suppl 1): R47-R58.
[9] MA. Factors affecting oocyte and embryo transcriptomes. Reprod Domest Anim , 2012, 47(Suppl. 4): 148-155.
[10] T, Arai Y, Umehara H, Masuhara M, Kimura T, Taniguchi H, Sekimoto T, Ikawa M, Yoneda Y, Okabe M, Tanaka S, Shiota K, Nakano T. PGC7/Stella protects against DNA demethylation in early embryogenesis. Nat Cell Biol , 2007, 9(1): 64-71.
[11] XJ, Ito M, Zhou F, Youngson N, Zuo XP, Leder P, Ferguson-Smith AC. A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev Cel , 2008, 15(4): 547-557.
[12] DM, De V W, Ito M, Solter D, Ferguson-Smith A, Knowles BB. Trim28 is required for epigenetic stability during mouse oocyte to embryo transition. Science , 2012, 335(6075): 1499-1502.
[13] R, Chiba H, Kaneda M, Tajima S, Li E, Jaenisch R, Sasaki H. Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev , 2008, 22(12): 1607-1616.
[14] T, Jones GM, Lolatgis N, Pera MF, Trounson AO, Monk M. Identification and characterisation of known and novel transcripts expressed during the final stages of human oocyte maturation. Mol Reprod Dev , 2002, 62(1): 13-28.
[15] B, Saitou M, Barton SC, Thresher R, Dixon JPC, Zahn D, Colledge WH, Carlton MBL, Nakano T, Surani MA. Stella is a maternal effect gene required for normal early development in mice. Curr Biol , 2003, 13(23): 2110-2117.
[16] A, Goodheart M, Liao M, Page DC. Dppa3 / Pgc7 /stella is a maternal factor and is not required for germ cell specification in mice. BMC Dev Biol , 2004, 4: 2.
[17] T, Liu YJ, Nakashima H, Umehara H, Inoue K, Matoba S, Tachibana M, Ogura A, Shinkai Y, Nakano T. PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos. Nature , 2012, 486(7403): 415-419.
[18] P, Su L, Wang ZW, Zhang S, Guan JY, Chen Y, Yin YP, Gao F, Tang B, L ZY. The involvement of 5-hydroxy-methylcytosine in active DNA demethylation in Mice. Biol Reprod , 2012, 86(4): 104.
[19] S, Tanase S, Choudhury BK, Setoyama K, Miura R, Ogawa M, Setoyama C. A novel nuclear protein with zinc fingers down-regulated during early mammalian cell differentiation. J Biol Chem , 1994, 269(9): 6900-6907.
[20] S, Verde G, Corsinotti A, Kapopoulou A, Jakobsson J, Offner S, Baglivo I, Pedone PV, Grimaldi G, Riccio A, Trono D. In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions. Mol Cell , 2011, 44(3): 361-372.
[21] FY, Baldwin DA, Schultz RM. Transcript profiling during preimplantation mouse development. Dev Biol , 2004, 272(2): 483-496.

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

母源效应蛋白在基因组印记维持中的作用

The roles of maternal-effect proteins in the maintenance of genomic imprints

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	许梦萱, 周明. 植物RNA聚合酶IV调控DNA甲基化和发育的研究进展[J]. 遗传, 2022, 44(7): 567-580.
[2]	王雅楠, 徐涛, 王万鹏, 张庆祝, 解莉楠. 表观遗传修饰在作物重要性状形成中的作用[J]. 遗传, 2021, 43(9): 858-879.
[3]	张向前, 李楠, 解新明. 表观遗传学综合性实验设计与探讨[J]. 遗传, 2021, 43(12): 1179-1187.
[4]	王芯悦, 李亮, 段秋慧, 李大力, 陈金联. Uhrf1对肠上皮发育的影响[J]. 遗传, 2021, 43(1): 84-93.
[5]	崔亨贞, 孙蜜烛, 王润芝, 李辰雨, 黄予暄, 黄秋菊, 乔晓孟. 内侧前额叶皮质DNA甲基化调控大鼠酒精相关行为[J]. 遗传, 2020, 42(1): 112-125.
[6]	王昕源, 张雨, 杨楠, 程禾, 孙玉洁. DNMT3a通过提升基因内部甲基化介导紫杉醇诱导的LINE-1异常表达[J]. 遗传, 2020, 42(1): 100-111.
[7]	黄鑫,陈永强,徐国良,彭淑红. 脂肪组织DNA甲基化与糖尿病和肥胖的发生发展[J]. 遗传, 2019, 41(2): 98-110.
[8]	杨旭琼, 吴珍芳, 李紫聪. 哺乳动物体细胞核移植表观遗传重编程研究进展[J]. 遗传, 2019, 41(12): 1099-1109.
[9]	潘云枫, 王演怡, 陈静雯, 范怡梅. 线粒体代谢介导的表观遗传改变与衰老研究[J]. 遗传, 2019, 41(10): 893-904.
[10]	鞠君毅,赵权. γ-珠蛋白基因表达调控机制与临床应用[J]. 遗传, 2018, 40(6): 429-444.
[11]	刘辰东, 杨露, 蒲红州, 杨琼, 黄文耀, 赵雪, 朱砺, 张顺华. 运动对骨骼肌基因表达的表观遗传调控作用[J]. 遗传, 2017, 39(10): 888-896.
[12]	张轲, 冯光德, 张宝云, 向伟, 陈龙, 杨芳, 储明星, 王凭青. 表观遗传标记在猪分子育种中的研究与应用前景[J]. 遗传, 2016, 38(7): 634-643.
[13]	朱屹然,张美玲,翟志超,赵云蛟,马馨. 生殖细胞及早期胚胎基因组印记的表观调控[J]. 遗传, 2016, 38(2): 103-108.
[14]	刘姝丽，张胜利，俞英. 同卵双胞胎在复杂性状DNA甲基化调控机制研究中的应用[J]. 遗传, 2016, 38(12): 1043-1055.
[15]	刘洋洋, 崔恒宓. DNA甲基化分析中重亚硫酸盐处理DNA转化效率的评估方法[J]. 遗传, 2015, 37(9): 939-944.